frameshift mutation

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read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
References in periodicals archive ?
2) Hanta FM, Reburying A, Pang M, Redman JOB, Sun W, Strom CM: Apparent homozygosity of a novel frame shift mutation in the CFTR gene because of a large deletion.
Frame shift mutations as a novel mechanism for the generation of neutralization resistant mutants of human respiratory syncytial virus.
His camera notes the link between declining cinema attendance and the rise of DVD culture - the frame shifts from an empty cinema to shots of pirated DVDs on sale at the local souq.
WHAT A PANE: A clear problem arises when a window frame shifts because the window supports are too weak
The frame shifts then to the road outside Semaan's house, where, over several minutes and scenes - and to the aural accompaniment of cows being milked - the sky gradually brightens over the mountains, the sun warming a shot of the ancient jalopy that is his car.