CX3CL1

(redirected from Fractalkine)

CX3CL1

A chemokine highly expressed in dendritic cells which is encoded by CX3CL1 on chromosome 16q13. CX3CL1 is thought to regulate leukocyte adhesion and migration in endothelium, given that membrane-bound CX3CL1 promotes adhesion of T cells and monocytes to endothelial cells.
References in periodicals archive ?
Fractalkine is essential for microglial cell migration.
Kancera's pharmaceutical candidate KAND567 works by blocking the Fractalkine system and has been shown in preclinical disease models to effectively counteract the onset of autoimmune disorders, as well as neuritis and pain in connection with chemotherapy against cancer.
Microglial signalling mechanisms: Cathepsin S and Fractalkine.
Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice.
Some factors such as eotaxin, fractalkine, macrophage inflammatory protein-1a, and thymus-expressed chemokine show chemokine activity and are involved in cell migration and adhesion.
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
The inflammatory status score including IL-6, TNF-[alpha], osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus," Acta Diabetologica, vol.
Two regions, each of which contained a single nucleotide polymorphism (SNP) site of the fractalkine receptor gene, were amplified.
In addition, the TNF-[alpha]-induced mRNA expression of fractalkine/CX3CLl and the level of soluble fractalkine were both reduced by Tanshinone IIA.
According to the company, MIV-247, which is also entering non-clinical development, is a potent and highly selective inhibitor of cathepsin S, an enzyme shown to be important for the maintenance of the neuropathic pain state, through its action in releasing fractalkine (a pro-inflammatory protein) in areas of the spinal cord important for pain sensation.
Olefsky, MD, associate dean for scientific affairs and distinguished professor of medicine, and colleagues said that a transmembrane binding protein called fractalkine, which typically mediates cell-to-cell adhesion though its receptor, CX3CR1, can also be released from cells to circulate in the blood and stimulate insulin secretion.
List of proteins analysed in Phase II samples: interleukin (IL)2, IL6, IL8, IL10, and tumor necrosis factor alpha, IL1[beta], IL4, IL5, IL7, IL13, interferon alpha, interferon gamma, eotaxin, fractalkine, interferon gamma-induced protein 10, granulocyte-macrophage colony stimulating factor, epidermal growth factor, fibroblast growth factor 2, granulocyte colony-stimulating factor, melanoma growth stimulatory activity/growth-related oncogene, monocyte chemotactic protein-1, monocyte chemotactic protein-3, macrophage derived chemokine, macrophage inflammatory protein 1 alpha, macrophage inflammatory protein 1 beta, soluble CD40 ligand, transforming growth factor alpha and vascular endothelial growth factor) using the milliplex HCYTOMAG-60SK and HSCYTMAG-60SK kits (Millipore, Billerica, MA).