CX3CL1

(redirected from Fractalkine)
Also found in: Wikipedia.

CX3CL1

A chemokine highly expressed in dendritic cells which is encoded by CX3CL1 on chromosome 16q13. CX3CL1 is thought to regulate leukocyte adhesion and migration in endothelium, given that membrane-bound CX3CL1 promotes adhesion of T cells and monocytes to endothelial cells.
References in periodicals archive ?
Kancera has entered into an agreement with Acturum Life Science AB in order to evaluate and further develop the unique Fractalkine inhibitor AZD8797.
In addition, the TNF-[alpha]-induced mRNA expression of fractalkine/CX3CLl and the level of soluble fractalkine were both reduced by Tanshinone IIA.
Cathepsin S is a member of the cysteine protease family of cathepsin inhibitors that catalyzes proteolytic cleavage of membrane-bound fractalkine from the surface of neurons to release soluble fractalkine.
Olefsky, MD, associate dean for scientific affairs and distinguished professor of medicine, and colleagues said that a transmembrane binding protein called fractalkine, which typically mediates cell-to-cell adhesion though its receptor, CX3CR1, can also be released from cells to circulate in the blood and stimulate insulin secretion.
List of proteins analysed in Phase II samples: interleukin (IL)2, IL6, IL8, IL10, and tumor necrosis factor alpha, IL1[beta], IL4, IL5, IL7, IL13, interferon alpha, interferon gamma, eotaxin, fractalkine, interferon gamma-induced protein 10, granulocyte-macrophage colony stimulating factor, epidermal growth factor, fibroblast growth factor 2, granulocyte colony-stimulating factor, melanoma growth stimulatory activity/growth-related oncogene, monocyte chemotactic protein-1, monocyte chemotactic protein-3, macrophage derived chemokine, macrophage inflammatory protein 1 alpha, macrophage inflammatory protein 1 beta, soluble CD40 ligand, transforming growth factor alpha and vascular endothelial growth factor) using the milliplex HCYTOMAG-60SK and HSCYTMAG-60SK kits (Millipore, Billerica, MA).
Epigallocatechin-3-O-gallate decreases tumor necrosis factor-alphainduced fractalkine expression in endothelial cells by suppressing NF-kappaB.
Based on the relative position of the cysteine residues in the protein sequence, they are classified into 4 subfamilies: CXC ([alpha]), CC ([beta]) chemokines, fractalkine (C[X.
3]CR1 icin fractalkine ile yanmaya girip fractalkine aracilikli immun yaniti degistirerek viral cogalmasini ve yasami ni devem ettirir (29).
fractalkine receptor) have been shown to be predictive of future atherosclerotic disease, further prospective studies, including a larger number patients, are needed to make any firm conclusion.
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.