founder effect

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Related to Founder population: Founder principle, Founder event

found·er ef·fect

an unusually high frequency of a gene in a particular population derived from a small set of unrepresentative ancestors.

founder effect

n.
A random difference in allele frequencies of a population founded by a small group of organisms relative to the allele frequencies in the original population.

founder effect

the result of starting a new population with a low number of individuals (founders), so that their GENE POOL may not contain the same proportions of ALLELES for a particular LOCUS as in the original population. For example, instead of containing three alleles of the ABO BLOOD GROUP locus, Australian aborigines contain no B alleles and thus no Group B or Group AB individuals are produced, a situation probably caused by a ‘founder effect’. Such small founder populations are subject to RANDOM GENETIC DRIFT.

founder effect

extreme genetic drift that occurs when a new population is based on only a few individuals ('founders'). Called also founder principle.
References in periodicals archive ?
It is well known from population studies that genetic variant frequencies vary widely across different global and founder populations, which can affect interpretation," said Van Zeeland.
We think there are 3 good potential reasons for genetic differentiation among Taoyuan, Meishan, and Berkshire pig breeds: i) founder population effect; ii) natural mating causing significant gene drift; and iii) a lack of an effective breeding program to maintain genetic diversity and enhance genetic differentiation.
Ultimately, gerontologists hope founder population studies yield results that will help prevent certain age-related diseases.
In early 2004, a whole WGAS was initiated on Crohn's disease in the Quebec founder population, which is more than 80% heritable.
These discoveries in our second landmark study, following the unprecedented discoveries in our first study in Crohn's Disease, confirm our belief that an LD-GWS using Quebec Founder Population DNA samples is one of the most powerful approaches to disease-gene/target discovery for common diseases.
Genome-wide search for asthma susceptibility loci in a founder population.
His laboratory published the first genome-wide association study of ALS in 2007, and was the first to identify an association signal for ALS on the short arm of chromosome 9 in the Finnish founder population in 2010.
By studying a founder population, the Hutterites, Ober's research maximizes genetic influences and minimizes non-genetic ones.
A founder population was created consisting of 1,000 animals with even sex ratio.
The recent completion of two landmark studies, one of the first genome-wide association studies for complex disease as well as the first genome-wide linkage disequilibrium map for a human population, demonstrates the power of the association approach using a founder population.
The Gypsies, or Roma, are what scientists call a founder population, a group started by a small number of isolated individuals who maintained genetic: idiosyncrasies over multiple generations (SN: 7/22/00, p.
Genizon's study identified multiple genes associated with the disease using DNA samples from the Quebec Founder Population.