founder effect

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Related to Founder effects: Founder principle, Founder event

found·er ef·fect

an unusually high frequency of a gene in a particular population derived from a small set of unrepresentative ancestors.

founder effect

n.
A random difference in allele frequencies of a population founded by a small group of organisms relative to the allele frequencies in the original population.

founder effect

the result of starting a new population with a low number of individuals (founders), so that their GENE POOL may not contain the same proportions of ALLELES for a particular LOCUS as in the original population. For example, instead of containing three alleles of the ABO BLOOD GROUP locus, Australian aborigines contain no B alleles and thus no Group B or Group AB individuals are produced, a situation probably caused by a ‘founder effect’. Such small founder populations are subject to RANDOM GENETIC DRIFT.

founder effect

extreme genetic drift that occurs when a new population is based on only a few individuals ('founders'). Called also founder principle.
References in periodicals archive ?
In particular, dominant disease is exemplified in the case of Alzheimer's disease by presenilin 2 mutations that arose in German immigrants from the Volga river region in the 17th century, [1] and in PD by mutations in the LRRK2 protein that are linked to a founder effect dating back to the 2nd century, probably in Ashkenazi Jews.
glacial refugia) through founder effects and bottlenecks as a result of multiple stepwise colonization events (Hewitt, 1996; Widmer and Lexer, 2001; Jim6nez et al.
The high gene frequency is due to founder effects and high incidence of consangious marriages in the above populations.
Model 3, the constrained founder effect model, also significantly increments the control model (Nagelkerke [R.
In some populations with founder effects, BRCA1/2 mutations are far more frequent and account for a greater proportion of familial aggregation and breast cancer overall.
The latter include migration, founder effect, neutral in situ differentiation, non-random mating and population size fluctuation (Cavalli-Sforza et al.
The literature on "rule governed" behavior is replete with bottlenecks and founder effects.
Loss of genetic diversity, both in wild and captive populations, raises concerns about the potential impact of inbreeding, genetic bottlenecks, and founder effects.
Several disorders among Afrikaners occur at relatively high frequencies due to founder effects.
On a larger scale, founder effects may explain why many continue to practice psychoanalysis/ psychodynamic therapy and its derivatives, despite little empirical support and more scientifically established interventions.
HHT is a vascular dysplasia that affects approximately 1 in 5 000 8 000 individuals, [1] with regional differences due to founder effects.