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Fosamax |
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alendronate sodium Fosamax Pharmacologic class: Bisphosphonate Therapeutic class: Bone-resorption inhibitor Pregnancy risk category C ActionImpedes bone resorption by inhibiting osteoclast activity, absorbing calcium phosphate crystal in bone, and directly blocking dissolution of hydroxyapatite crystal of bone AvailabilityTablets: 5 mg, 10 mg, 35 mg, 40 mg, 70 mg ⊘Indications and dosages ➣ Paget's disease of bone Adults: 40 mg P.O. daily for 6 months ➣ Prevention of osteoporosis in postmenopausal women Adults: 5 mg P.O. daily or 35 mg P.O. once weekly ➣ Glucocorticoid-induced osteoporosis in adults with low bone mineral density who are receiving daily glucocorticoid doses equivalent to 7.5 mg or more of prednisone Adults: 5 mg P.O. daily. For postmenopausal women not receiving estrogen, recommended dosage is 10 mg P.O. once daily. ➣ Osteoporosis in postmenopausal women; to increase bone mass in men with osteoporosis Adults: 10 mg P.O. daily or 70 mg P.O. once weekly Contraindications• Hypersensitivity to bisphosphonates PrecautionsUse cautiously in: Administration• Give with 6 to 8 oz of water before first food, beverage, or medication of day.
Adverse reactionsCNS: headache CV: hypertension GI: nausea, vomiting, diarrhea, constipation, abdominal pain, acid regurgitation, esophageal ulcer, flatulence, dyspepsia, abdominal distention, dysphagia GU: urinary tract infection Hematologic: anemia Metabolic: hypomagnesemia, hypophosphatemia, hypokalemia, fluid overload Musculoskeletal: bone or muscle pain Skin: rash, redness, photosensitivity Other: abnormal taste InteractionsDrug-drug. Antacids, calcium supplements: decreased alendronate absorption NSAIDs, salicylates: increased risk of GI upset Ranitidine: increased alendronate effect Drug-diagnostic tests. Calcium, phosphate: decreased levels Drug-food. Any food, caffeine (as in coffee, tea, cocoa), mineral water, orange juice: decreased drug absorption Patient monitoring• Monitor for signs and symptoms of GI irritation, including ulcers. Patient teaching☞ Tell patient to immediately report serious vomiting, severe chest or abdominal pain, difficulty swallowing, or abdominal swelling. Fosamax® Alendronate, see there How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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obtained manufacturing approval for Fosamax Plus D - generic name: aledronate sodium - on July 26. Food and Drug Administration (FDA) approved Fosamax (alendronate), the first drug shown to increase bone mass and significantly reduce the risk of fractures in women who already have osteoporosis. Increasingly, experts are studying the possibility of using a combination of estrogen therapy or SERMS with Fosamax (alendronate), a biophosphonate approved in 1995 for the treatment of women with osteoporosis. |
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