Keywords: Amines, Formylation, H2SO4/Activated charcoal, Ethyl formate.
They are also a highly useful class of intermediates in the synthesis of pharmaceutically important compounds such as fluoroquinolines , cancer chemotherapeutic agents , oxazilidones , Vilsmeier-Haake formylation reaction , nitriles , hydrosilylation of carbonyl compounds , 1-arylimi-dazole-5-carboxylates , 1-formyl-1,2-dihydroquinolines , nitrogen bridged heterocycles , fungicides [8, 11], isocyanates , formamidines  and allylation reaction .
Formylation of aniline in the absence of sulfuric acid and activated charcoal did not any take place (entry 1), however, the reaction of 1 mmol of aniline with the alone H2SO4 (0.
During the formylation reaction, functionality of alkyl, nitro, halogen and carbonyl remained intact.
Shuhaibar, Vilsmeier Formylation and Glyoxylation Reactions of Nucleophilic Aromatic Compounds Using Pyrophosphoryl Chloride, Tetrahedron, 49, 4015 (1993).
However, functionalization of porphyrin derivatives had been limited to electrophilic substitution such as halogenation, nitration and formylation
, which proceed selectively at the meso-positions in the case of meso-unsubstituted porphyrins such as 15 (Scheme 9).
That is the reason why, in the present article, the starch formylation was included in a one step reactive extrusion process.
The modification by FA has been shown to yield a decrease of the difference of the relaxation times between starch and PCL characteristic chemical groups, proving that the formylation of starch improved the miscibility of starch with PCL.
Rajput, Synthesis of benzaldehyde substituted phenyl carbonyl hydrazones and their formylation
using Vilsmeier-Haack reaction, International Journal of PharmTech Research, 1, 1605 (2009), and literature cited therein; (b) M.