dicyclomine

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dicyclomine

 [di-si´klo-mēn]
an anticholinergic and antimuscarinic with effects similar to those of atropine; the hydrochloride salt is used as a gastrointestinal antispasmodic.

dicyclomine (dicycloverine (UK))

Bentyl, Bentylol (CA), Diclophen (CA), Formulex (CA), Lomine (CA), Merbentyl (UK), Protylol (CA)

Pharmacologic class: Anticholinergic

Therapeutic class: Antispasmodic

Pregnancy risk category B

Action

Thought to exert direct effect on GI smooth muscle by inhibiting acetylcholine at receptor sites, thereby reducing GI tract motility and tone

Availability

Capsules: 10 mg

Solution for injection: 10 mg/ml

Syrup: 10 mg/5 ml

Tablets: 20 mg

Indications and dosages

Irritable bowel syndrome in patients unresponsive to usual interventions

Adults: 20 mg P.O. or I.M. q.i.d.; may increase up to 160 mg/day

Contraindications

• Hypersensitivity to drug
• GI or genitourinary tract obstruction
• Severe ulcerative colitis
• Reflux esophagitis
• Unstable cardiovascular status
• Glaucoma
• Myasthenia gravis

dicyclomine

/di·cy·clo·mine/ (-si´klo-mēn) an anticholinergic, used as the hydrochloride salt as a gastrointestinal antispasmodic.

dicyclomine

(dī-sī′klə-mēn′)
n.
An anticholinergic drug, C19H35NO2, used in its hydrochloride form to relax smooth muscle and as an antispasmodic in the treatment of irritable bowel syndrome and other gastrointestinal disorders.

dicyclomine

an anticholinergic; the hydrochloride is used as a gastrointestinal antispasmodic.
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