FOLH1

(redirected from Folate hydrolase 1)

FOLH1

A gene on chromosome 11p11.2 that encodes folate hydrolase 1, which has both folate hydrolase (FH) and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. It acts as an FH in the intestine and is required for the uptake of folate; in the brain, it modulates excitatory neurotransmission by hydrolysing the neuropeptide N-aceylaspartylglutamate (NAAG), releasing glutamate. It is highly expressed in the prostate.
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Prostate-specific membrane antigen (PSMA; also known as folate hydrolase 1, glutamate carboxypeptidase II or NAALA-Dase) presents a novel endothelial target.