FLT1

(redirected from Fms-like tyrosine kinase 1)

FLT1

A gene on chromosome 13q12 that encodes a member of the vascular endothelial growth factor receptor (VEGFR) family of receptor tyrosine kinases (RTKs), which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment and a tyrosine kinase (TK) domain within the cytoplasmic domain. FLT1 binds to VEGFR-A, VEGFR-B and placental growth factor, plays an important role in angiogenesis and is expressed in vascular endothelial cells, placental trophoblast cells and monocytes.
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MIAMI BEACH -- Serum levels of soluble endoglin and soluble fms-like tyrosine kinase 1 are increased months before onset of clinical disease in patients with preeclampsia, Dr.
We believe that soluble endoglin [a cell surface receptor for the proangiogenic protein transforming growth factor-[beta] and soluble fms-like tyrosine kinase 1 [an antiangiogenic factor that binds placental growth factor and vascular endothelial growth factor] act in concert to produce the maternal syndrome or preeclampsia," he said.
Both new studies examined pregnant women's blood concentrations of placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt1).
The rights are specific to the combined use of soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) for the diagnosis of vascular diseases.
The gene encoding a protein called soluble fms-like tyrosine kinase 1 (sFlt1) was overactive in the preeclamptic placentas.