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Fluorouracil

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
fluorouracil /flu·o·ro·ura·cil/ (5-FU) (floor?o-ur´ah-sil) an antimetabolite activated like uracil, used as a systemic and topical antineoplastic.
fluor·o·u·ra·cil (flr-yr-sl, flôr-)
n.
An antineoplastic agent used especially in the treatment of cancers of the skin, breast, and digestive system.
Fluorouracil
A cell-killing (cytotoxic) medication that can be applied in cream form to treat cancer of the penis.
Mentioned in: Penile Cancer
fluorouracil (topical) (flr´yr´sil),
n brand names: Efudex, Fluoroplex;
drug class: topical antineoplastic;
action: inhibits synthesis of DNA and RNA in susceptible cells;
uses: keratosis, basal cell carcinoma.
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The combination regimen CapeOX, which is capecitabine (Xeloda, Roche) and oxaliplatin (Eloxatin, sanofi~aventis), was added as an alternate option to the combination of fluorouracil, leucovorin and oxaliplatin (known as FOLFOX).
NCCN Updates Colon Cancer Guidelines by Business Wire
The company has already received ANDA approvals in the United States for seven generic oncology drugs, including Fluorouracil and Methotrexate, but only in vials for injection.
SWISS IKS APPROVES FORMULATION OF METRONIDAZOLE IN IV BAGS by Worldwide Biotech
In the first study, researchers in the National Surgical Adjuvant Breast and Bowel Project (NSABP) studied 679 node-negative patients, finding that women given chemotherapy -- a combination of methotrexate and fluorouracil - had an 80 percent disease-free survival rate four years later, compared with 71 percent of controls.
Drugs give slight edge in breast cancer by Fackelmann, Kathy A. / Science News
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