TETS meets criteria for inclusion in the list of extremely hazardous pesticides maintained by the World Health Organization (WHO) and is more lethal than WHO's most toxic registered pesticide, sodium fluoroacetate
In Australia, some 35 plant species, in three legume genera, are known to produce fluoroacetate.
Laurie Twigg, the late Dennis King, Gary Martin, and others, from the Department of Agriculture Western Australia, have shown that many native animals in such regions, especially plant-eating ones, have evolved a marked tolerance to fluoroacetate, having co-existed with the toxic vegetation for thousands of years.
The lower tolerance of some northern Australian bird species may have resulted from the lower levels of fluoroacetate in toxic plants in the north of the state than in the south.
The co-evolutionary role of fluoroacetate
in plant-animal interactions in Australia.
Groth noted that some plants can synthesize organic fluoride compounds like fluoroacetates
which Fluoride Quarterly Reports identified as "among the most poisonous substances known.
Isolation and identification of sodium fluoroacetate degrading bacteria from caprine rumen in Brazil.
Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning.
Sliced potato and squash were used as fresh bait with sodium fluoroacetate
and strychnine to achieve 88% and 40% reduction in Indian porcupine burrow activity, respectively (Khan et al.
These native species contain the poison sodium fluoroacetate
, which is manufactured synthetically as 1080.
Tests show that the victims had heart attacks or stopped breathing after being given banned rat poison sodium fluoroacetate
It is therefore the aim of this project to look at the chemical constituents other than the fluoroacetates
and fluorofatty acids that might account for medicinal properties of the plant.