flumazenil


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flumazenil

 [floo-ma´zĕ-nil″]
a benzodiazepine agonist that competitively binds to receptor sites in the central nervous system; used to reverse the effects of benzodiazepines after sedation, general anesthesia, or overdose.

flu·ma·ze·nil

(flū'mā-zē-nil),
A benzodiazepine with antagonist properties at the benzodiazepine recognition site of the benzodiazepine-GABA-chloride channel complex. Used as a treatment for overdose with benzodiazepine-type central nervous system depressants, or for controlled reversal of anesthesia induced by such agents.

flumazenil

/flu·ma·ze·nil/ (floo-ma´zĕ-nil″) a benzodiazepine agonist used to reverse the effects of benzodiazepines after sedation, general anesthesia, or overdose.

flu·ma·ze·nil

(flū'mā-zē'nil)
Benzodiazepine with antagonist properties at the benzodiazepine recognition site of the benzodiazepine gamma-aminobutyric acid-chloride channel complex. Used to treat overdose with benzodiazepine-type central nervous system depressants or controlled reversal of anesthesia induced by such agents.

flumazenil

A drug that opposes the action of BENZODIAZEPINE drugs and can be used to reverse their sedating effect. A brand name is Anexate.

flu·ma·ze·nil

(flū'mā-zē'nil)
Benzodiazepine with antagonist properties used to treat overdose with benzodiazepine-type central nervous system depressants, or for controlled reversal of anesthesia induced by such agents.

flumazenil

(floo´mazənil´),
n brand name: Romazicon;
drug class: benzodiazepine receptor antagonist;
action: antagonizes actions of benziodiazepines on the central nervous system;
use: reversal of sedative effects of benzodiazepines.

flumazenil

a benzodiazepine antagonist.
References in periodicals archive ?
Six hours after administration there was no response to the flumazenil.
After completion of endoscopy, the midazolam was reversed with flumazenil (0.
Unfortunately, midazolam is a category D drug during pregnancy, and interestingly, it is completely antagonised by flumazenil (category C drug).
Individual differences in aggressive responding to intravenous flumazenil administration in adult male parolees.
5) because its effects were antagonized by flumazenil, a [GABA.
She was treated with IV cogentin and flumazenil with positive and immediate effect.
DENVER -- Transdermal or sublingual flumazenil is well worth considering for treatment of carefully selected patients with hypersomnolence refractory to conventional wake-promoting medications, Lynn Marie Trotti, MD, said at the annual meeting of the Associated Professional Sleep Societies.
The skin, subcutaneous tissue and the periosteum, were infiltrated with 2% lignocaine for local anaesthesia, and younger patients received sedation with Midazolam, 5-10mg intravenously (IV ), which was reversed with flumazenil after the procedure.
Aside from standard cardiopulmonary measures in calcium channel blocker overdoses, additional commonly employed resuscitative therapies have included gastric lavage, multi-dose oral or nasogastric activated charcoal, flumazenil infusion, naloxone infusion, insulin and glucagon intravenous boluses, continuous calcium gluconate infusion, intravenous antiarrhythmics as indicated, and vasopressor support during mechanical ventilation.
Two chlorzoxazone (Parafon forte) overdoses and coma in one patient: reversal with flumazenil.
Effect of flumazenil on recovery from general anesthesia with isoflurane: A randomized controlled trial *