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fludarabine |
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fludarabine /flu·dar·a·bine/ (floo-dar´ah-bēn) an adenine analogue and purine antimetabolite used as the phosphate salt as an antineoplastic in the treatment of chronic lymphocytic leukemia. fludarabine, an antimetabolite used to treat neoplasia. indications It is prescribed in the treatment of patients with B-cell chronic lymphocytic leukemia and as salvage therapy for non-Hodgkin's lymphoma and acute leukemias. contraindications It should not be given to patients who are pregnant or hypersensitive to this drug or its components. Patients should be closely observed for signs of hematologic and nonhematologic toxicity (e.g., edema, fatigue, myalgias). adverse effects It is a potent antineoplastic agent with potentially significant side effects. The side effects most often reported include myelosuppression, fever and chills, nausea, and vomiting. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Anderson Cancer Center in Houston reports preliminary results from a trial of CLL patients given the experimental drug fludarabine. including, Amifostine, Carboplatin USP, Cisplatin USP, Doxorubicin HCl USP, Epirubicin HCl EP, Etoposide USP, Fludarabine Phosphate, Gemcitabine HCl USP, Ifosfamide USP, Irinotecan HCl 3H2O, Mitoxantrone HCl USP/PhEur and Thiotepa USP. Biogen Idec (Nasdaq: BIIB) announced data from a Phase I/II study of an investigational anti-CD23 monoclonal antibody, lumiliximab, suggesting it may be synergistic with fludarabine, cyclophosphamide and rituximab (FCR), an emerging standard of care for chronic lymphocytic leukemia (CLL) patients. |
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