KDR

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KDR

A gene on chromosome 4q11-q12 that encodes a vascular endothelial growth factor receptor known as kinase insert domain receptor, which is a type-III receptor tyrosine kinase. KDR is the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting.

Molecular pathology
KDR mutations have been linked to infantile capillary haemangiomas.
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VEGF and Flk-1 were immunolocalized in the luminal epithelium, glandular epithelium and stroma of the endometrium at various phases of the menstrual cycle (Figures 2 and 3, A-E).
Table 2 summarizes the HSCOREs of VEGF and Flk-1 in the endometrium during the menstrual cycle.
Expression of Flk-1 showed distinct patterns and changes during the menstrual cycle (Figures 2AE, Table 2).
reported that VEGF and its receptor Flk-1 (KDR) were expressed in both glandular epithelial and stoma cells during the mid-secretory phase as well as in decidual cells of early pregnancy (3).
In the present study, Flk-1 expression showed distinct patterns and changes during the phases of the cycle.
In our study, variation in the expression of VEGF in stroma and differential expression of Flk-1 in different compartments during menstrual cycle may reflect the balance of steroid hormone's effect in the dynamic changes of the cycle.
In both groups, the number of clusters dissipated within 7 days of culture, giving rise to spindle-shaped cells (Figure 4A), which stained positive for Sca-1 and Flk-1, as well as for acLDL and UE-lectin (Figure 4C).