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Flexner-Wintersteiner Rosette

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
rosette /ro·sette/ (ro-zet´) [Fr.] any structure or formation resembling a rose, such as (a) the clusters of polymorphonuclear leukocytes around a globule of lipid nuclear material, as observed in the test for disseminated lupus erythematosus, or (b) a figure formed by the chromosomes in an early stage of mitosis.
Flexner-Wintersteiner rosette  a spoke- and wheel-shaped cell formation seen in retinoblastoma and certain other ophthalmic tumors.
Homer Wright rosette  a circular or spherical grouping of dark tumor cells around a pale, eosinophilic, central area that contains neurofibrils but lacks a lumen; seen in some medulloblastomas, neuroblastomas, and retinoblastomas or other ophthalmic tumors.

Flexner-Wintersteiner Rosette
A structure seen by light microscopy which consist of ‘bland’ nuclei arranged around a fibrillary background of axonal material, which are virtually pathognomonic for well-differentiated retinoblastomas


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