high mo·lec·u·lar weight ki·nin·o·gen (HMWK),
a plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein.
a high-molecular-weight kininogen, a blood clotting factor.