In a presentation entitled, "Development of a Tri-Valent, Attenuated, rVSV-Vectored Vaccine for Single Dose Protection Against All Filovirus
Of these contigs, 3 (129-354 nt) were genetically close to filovirus
, corresponding to the nucleoprotein gene of LLOV (74% nt identity), the viral protein 35 gene of Sudan Ebola virus (69% nt identity), and the L gene of Tai Forest Ebola virus (72% nt identity) (online Technical Appendix Table 1, http://www.
The reservoir for filovirus
has remained a huge mystery.
His research interests include the genomic study of filovirus
and orthopoxvirus infections.
The grant will support development of a trivalent vaccine to protect against infection with all major strains of Ebola and Marburg viruses, the two members of the filovirus
family of hemorrhagic fever viruses.
RT-PCR Kit, which does not fall under the EUA, outside the United States.
This CRADA utilizes Biovest's hollow fiber technology for production of vaccines, virus-like particles (VLPs) and antibodies for treatment and prevention of filovirus
diseases including those caused by Ebola and Marburg viruses.
One study showed that a single vaccination, using a vaccine made from multiple VSV filovirus
vaccines, affords protection against an otherwise lethal challenge with distinct EBOV species and a MARV isolate (6).
The Consortium, whose plan is closely aligned with the WHO position paper on collection and use of convalescent plasma or serum as an element in Filovirus
outbreak response, expects to begin clinical trials in November 2014.
We are continuing to develop a trivalent vaccine that will protect our service members and DoD civilians against the major filovirus
threats: Ebola Zaire, Ebola Sudan, and Marburg viruses," said LTC Victor Suarez, MCS-JVAP Joint Product Manager.
This finding was surprising because no filovirus
has been reported in the region or in West Africa other than the initial isolation of TAFV in Cote d'Ivoire (36).
In light of the current outbreak of Ebola in Western Africa, we are grateful that the Department of the Army has recognized the potential of Profectus' VesiculoVax(TM) rVSV-vectored filovirus
vaccine to counter biowarfare threats, and Profectus BioSciences is confident it will also have application with regard to protecting civilians and military personnel against highly lethal emerging infectious diseases," said John Eldridge, PhD, Chief Scientific Officer of Profectus.