FBLN2

(redirected from Fibulin-2)

FBLN2

A gene on chromosome 3p25.1 that encodes fibulin-2, a secreted glycoprotein of the fibulin family that binds various extracellular ligands and calcium and plays a key role during organogenesis, especially during the differentiation of the heart, muscle and brain.
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Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury.
A potential involvement of elastic fiber alteration in diabetic arteriopathy was underscored by our observation that transcripts for elastin and other elastin-related molecules were increased in diabetic arteries, including fibulin-2 (25), as well as MMP-2, a protease capable of degrading elastin (32) and previouslyfound to be upregulated in diabetes (11, 12).
73 protein LCCL domain containing 2 FBBLN2 Fibulin-2 1.