For example, CXC-chemokine ligand 16 (CXCL16) (a transmembrane CXC chemokine) knockout mice administrated with angiotensin II (Ang II) were found to have significantly less circulating fibrocytes
in injured kidney compared with these in wild-type mice,[sup] indicating CXCL16 is one of the mediators involved in circulating fibrocyte
In 2003, researchers determined that the fibrosis of NFD seemed to be mediated by cells arriving via the circulation--so called circulating fibrocytes
In addition, the effect of hPTX-2 on activation of hepatic stellate cells and fibrocytes
into collagen producing cells was tested in vitro.
Analysis of efficacy biomarkers comparing healthy volunteers and IPF patients showed a 50% reduction of CD45+/collagen-1+ fibrocytes
within peripheral blood of all IPF patients at 24 hours, and fibrocytes
remained suppressed for up to 21 days in the majority of patients.
By showing that PTX-2/SAP has dominant therapeutic effects even downstream of TGF1 pathways through the ability to inhibit pathologic fibrocytes
and macrophages and promote regulatory macrophage function, these results further confirm that Pentraxin-2 regulates fundamental mechanisms of the innate immune system, opening an exciting new approach to treat inflammatory and fibrotic diseases.
Stroma of terminal villi is friable, contains fibrocytes
Cysts lay within a loose stroma rich in mucinous and proteinaceous floccular fluid, among which widely dispersed reactive fibroblasts and fibrocytes
, and several bundles of smooth muscle fibers were present.
CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes
," Proceedings of the National Academy of Sciences of the United States of America, vol.
Fibromas are benign neoplasms of fibrocytes
with abundant collagenous stroma which has a rare occurrence in large animals.
It should be noted that there are differences between scar tissue and fibroma-type tumoral tissue, as described by MOVASSAGHI & MOHAMMADI (2009), where the fibroma presents mature fusiform fibrocytes
with oval normochromatic nuclei and abundant collagen organized in bundles.
The underlying sub-mucosa showed hypervascular granulation tissue, where as the fibrocytes
were arranged parallel to the serosa.
Older lesions demonstrate fewer and more mature cells, which are fibrocytes