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fibrocystic disease |
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fibrocystic disease, n See disease, fibrocystic. fibrocystic disease Chronic cystic mastitis, fibrocystic disease Surgical pathology A common benign disease of the ♀ breast, first seen circa age 40, which presents as diffuse rubbery induration, punctuated by dilated ducts and
variably-sized cysts Major patterns Cysts plus fibrosis; sclerosing adenosis; epithelial hyperplasia, which ↑ CA risk. See Ductal intraepithelial neoplasia.
fibrocystic disease
No risk for future cancer: FCD with adenosis–sclerosing or florid, apocrine metaplasia, cysts–macro- or microscopic, ductal ectasia, fibroadenoma, fibrosis, hyperplasia
Minimal risk for future cancer: with glandular 'crowding', ie 2-4 epithelial cells in depth, mastitis, especially periductal, squamous metaplasia
1.5-2-fold ↑ risk of future cancer: with hyperplasia–moderate or florid, solid or papillary or in a papilloma with a fibrovascular core
2-5-fold ↑ risk of future cancer: with atypical hyperplasia–borderline lesion, either ductal or lobular
8-10-fold ≠ risk of future invasive cancer Carcinoma-in-situ
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Tissue was obtained when available from all subjects who underwent breast surgery after pathologic review in which tissue was classified as benign (including fibroadenomas, fibrocystic disease, and histologically normal tissue), cancer adjacent, or cancerous. Since my early 40s, when my breasts became lumpy and painful with a benign condition called fibrocystic disease, I was so afraid of breast cancer that I avoided every mention of it. is a 15-minute, non-invasive, image-screening procedure that detects the subtle physiologic changes that accompany breast pathology, whether it is cancer, fibrocystic disease, an infection or a vascular disease. |
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