FGFR3

(redirected from Fibroblast growth factor receptor-3)
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FGFR3

A gene located on chromosome 4p16.3, which encodes fibroblast growth-factor receptor 3, one of the mitogenic signalling molecules with roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development.

Molecular pathology
Mutations are linked to achondroplasia, craniosynostosis and multiple forms of skeletal dysplasia. It is up-regulated in cell transformation and some cancers.
References in periodicals archive ?
Fibroblast Growth Factor Receptor-3 Research - Abstract B241
ImClone Systems scientists presented preclinical data on the use of an antibody designed to inhibit the Fibroblast Growth Factor Receptor-3 (FGFR-3) in a xenograft mouse model of human prostate cancer.

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