FGFR3

(redirected from Fibroblast growth factor receptor 3)
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FGFR3

A gene located on chromosome 4p16.3, which encodes fibroblast growth-factor receptor 3, one of the mitogenic signalling molecules with roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development.

Molecular pathology
Mutations are linked to achondroplasia, craniosynostosis and multiple forms of skeletal dysplasia. It is up-regulated in cell transformation and some cancers.
References in periodicals archive ?
A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome.
The assay detects fibroblast growth factor receptor 3 (FGFR3) mutations, which studies have shown are present in 30 - 50% of bladder cancer patients.
DISCUSSION: Achondroplasia is inherited as autosomal dominant trait with complete penetrance, caused by mutation in a gene Fibroblast growth factor receptor 3 (FGR3) located on ch locus 4p16.
senior scientist at Predictive Biosciences and first author, will present the poster, which demonstrates how the performance of Predictive's bladder cancer assay was improved by utilizing both Matrix Metalloproteinase (MMP) biomarkers and Fibroblast Growth Factor Receptor 3 (FGFR3) biomarkers, leveraging the sensitivity and specificity achieved by each.
Specific targets include insulin-like growth factor-1 receptor (IGF-1R), vascular endothelial growth factor receptor-1 (VEGFR-1), VEGFR-2, VEGFR-3, platelet-derived growth factor receptor alpha (PDGFRa), FMS-like tyrosine kinase 3 receptor (FLT3), fibroblast growth factor receptor 3 (FGFR3), among others.

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