FGFR3

(redirected from Fibroblast growth factor receptor 3)
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FGFR3

A gene located on chromosome 4p16.3, which encodes fibroblast growth-factor receptor 3, one of the mitogenic signalling molecules with roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development.

Molecular pathology
Mutations are linked to achondroplasia, craniosynostosis and multiple forms of skeletal dysplasia. It is up-regulated in cell transformation and some cancers.
References in periodicals archive ?
The association of fibroblast growth factor receptor 3 (FGFR3) expression with t(4;14) multiple myeloma and the demonstration of the transforming potential of this receptor tyrosine kinase (RTK) make it a particularly attractive target for the development of anti cancer drugs.
Specific targets include insulin-like growth factor-1 receptor (IGF-1R), vascular endothelial growth factor receptor-1 (VEGFR-1), VEGFR-2, VEGFR-3, platelet-derived growth factor receptor alpha (PDGFR[eth]), FMS-like tyrosine kinase 3 receptor (FLT3), fibroblast growth factor receptor 3 (FGFR3), among others.

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