fibril

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Related to Fibrils: amyloidosis, collagen fibrils

fibril

 [fi´bril]
a minute fiber or filament. adj., adj fi´brillar, fi´brillary.
collagen f's delicate fibrils of collagen in connective tissue, composed of molecules of tropocollagen in linear array. In Type I collagen, the most common type, the tropocollagen molecules are associated in periodic, staggered arrays that give the appearance of cross-banding, forming unit fibrils; these unit fibrils are aggregated in bundles to form larger fibrils, with longitudinal striations, which may themselves be aggregated into fibers.
muscle fibril myofibril.

fi·bril

(fī'bril),
A minute fiber or component of a fiber.
Synonym(s): fibrilla
[Mod. L. fibrilla]

fibril

/fi·bril/ (fi´bril) a minute fiber or filament.fibril´larfib´rillary
collagen fibrils  delicate fibrils of collagen in connective tissue, composed of molecules of tropocollagen aggregated in linear array.
Enlarge picture
Type I collagen fibril (A); it is composed of unit fibrils, here shown negatively stained (B). The unit fibrils themselves comprise tropocollagen molecules in regular staggered arrays (C, D).
dentinal fibrils  component fibrils of the dentinal matrix.
muscle fibril  myofibril.

fibril

(fī′brəl, fĭb′rəl)
n.
1. A small slender fiber or filament.
2. Anatomy A threadlike fiber or filament, such as a myofibril or neurofibril, that is a constituent of a cell or larger structure.
3. A long strand of proteins that are aggregated together in a beta-sheet structure; an amyloid fibril.

fi′bril·lar (-lər), fi′bril·lar′y (-lĕr′ē) adj.
fi′bril·lose′ (-lōs′) adj.

fibril

[fī′bril]
Etymology: L, fibrilla, small fiber
a small filamentous fiber that often is a component of a cell, as in a mitotic spindle or a myofibril. fibrillary, adj.

fi·bril

(fī'bril)
A minute fiber or component of a fiber.
Synonym(s): fibrilla.

fibril

A fine, slender fibre.

fibril

a small FIBRE.

fibril

minute fibre

fibril

a minute fiber or filament.
References in periodicals archive ?
If the mutant protein did not concentrate into droplets, however, toxic fibrils did not form.
This fact is mentioned by some authors usually in the cases when the diameter of fibrils exceeds that of original particles [25, 26], This effect was studied by Fakirov who suggested end-to-end coalescence and detrimental effect of compatibilizers on fiber length because of suppression of coalescence.
The final beta-sheets bind together and stack up to form the damaging fibrils.
Washington, May 28 (ANI): For years, scientists and doctors have believed that protein aggregates called amyloid fibrils found in the brain were the culprit behind Alzheimer's disease.
The PPEBM-20 extrudate surface composed of coalesced PP fibrils, which did not break into droplets.
Barber and Hang used scanning electron microscopy (SEM) to image the fibrils, which measure less than 100 nanometres across - over 1000 times as thin as a human hair.
In contrast, in air, the existence of fibrils was no longer evident on the fracture surface of both specimens.
1A show numerous holes of various sizes, but no convincing evidence of cellulosic fibrils.
Twenty-eight different proteins can form amyloid, and it is critically important to know which is deposited in the fibrils of each patient.
An alternative approach to the treatment of Alzheimer's disease relies upon inhibiting aggregation of amyloid fibrils with the goal of reducing levels of soluble amyloid-beta peptide.
Chapters address identification of amyloid fibrils, in vivo imaging of amyloid fibrils, diagnosis and classification, pathogenesis of systemic amyloidosis, supportive care, response assessment and prognosis in evaluating patients with immunoglobin light chain amyloidosis, amyloid heart disease, amyloid neuropathy, treatment of immunoglobin light chain amyloidosis, high dose therapy with stem cell replacement, transthyretin amyloidosis, and rare forms of amyloidosis.
Ultrastructurally, mesangial matrix is composed of fine fibrils, which usually measure 6 to 8 nm in diameter.