fibrate


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Related to fibrate: niacin, Fenofibrate, ezetimibe, statin

fibrate

(fī-brāt),
An alternate term for fibric acid derivatives used to treat hyperlipidemia.

fibrate

(fi'brat?)
Any of a class of carboxylic acid compounds commonly used as lipid-lowering medications, including gemfibrozil and fenofibrate, that primarily reduce levels of triglycerides. Medications of this class have a minor impact on low-density and high-density lipoprotein cholesterol.
Synonym: fibric acid derivative

fibrate

One of a class of drugs capable of lowering the levels in the body of lipids (fats) including cholesterol. Fibrates can reduce low-density lipoproteins and raise high density lipoproteins. Some act by interfering with cholesterol synthesis in the liver others by promoting the more rapid breakdown of lipoproteins.
References in periodicals archive ?
Abbott's TriLipix is part of a class of drugs called fibrates that raise "good" HDL cholesterol while reducing triglycerides and "bad" LDL cholesterol.
Initial treatment is directed at the predominant abnormality, using a fibrate for patients with predominant hypertriglyceridaemia and a statin if high LDLC is the major problem.
Although human liver expresses around 10-fold less PPAR[alpha] mRNA than the rodent liver (27,28), evidence suggests that the hypolipidemic effects of the fibrate drugs in humans are also mediated by activation of PPAR[alpha], leading to regulation of the apolipoprotein (Apo) genes such as ApoA1 (29).
Treatment of moderate hypertriglyceridemia with fibrates has not been shown to reduce CV or total mortality.
They received dietary restrictions, omega3 fatty acid, statin, and/or fibrate.
Combination therapy with fibrates or niacin is common clue to concurrent high TG and low HDL levels in these patients (A).
This collaboration has the potential to provide physicians and patients with the first statin and fibrate combination in a single pill to comprehensively manage lipids.
Combinations consisting of a statin and niacin are the most popular, but combinations of a statin and a fibrate or a statin and a bile acid sequestrant are also used.
refer to clinical studies on clofibrate and gemfibrozil in male subjects as providing evidence of "an absence of a human cancer risk" for fibrate PPs.
Fenofibrate is the preferred fibrate to use in combination with a statin.
However, fibrates are also associated with rare hepatotoxicity and rhabdomyolysis, especially when combined with statins; therefore, liver function and creatine kinase (CK) levels should be checked 6 weeks after initiating fibrate therapy and every 3 to 6 months thereafter, or if symptoms appear.
There is also evidence that serum GGT activity decreases in hypertriglyceridemic patients after treatment with a fibrate (6, 7).