To assess the effects of statin and fibrate
therapies on incident cardiovascular events in an elderly population, the investigators analyzed data from an ongoing cohort study of vascular disease among elderly residents of Bordeaux, Dijon, and Montpellier.
4) reviewed 77 patients with rhabdomyolysis due to fibrate
Ginsberg said the data should ease some safety concerns of adding a fibrate
to statin therapy.
drugs were developed using rodent models to treat hyperlipidemia in humans before the receptor was identified.
consider taking statins, niacin, or a fibrate
drug, depending on your triglycerides and your other risk factors.
Liver enzyme elevations occur more frequently when either niacin or a fibrate
is combined with a statin drug, and these enzyme levels should be checked more frequently in patients on this combination.
Another group in which fibrate
therapy might be reasonably considered are those with a triglyceride level above 200 mg/dL and an HDL level below 35 mg/dL.
Abbott's TriLipix is part of a class of drugs called fibrates
that raise "good" HDL cholesterol while reducing triglycerides and "bad" LDL cholesterol.
Treatment of hypertriglyceridaemia should include lifestyle changes, exclusion and control of secondary factors and fibrate
LCP-AtorFen, the combination of one of the most potent and safe statins (atorvastatin) plus a safe and efficacious fibrate
(fenofibrate), opens the opportunity to address all angles of the atherogenic triad (LDL-C, HDL-C and Triglycerides) in one single pill", said Dr.
When Baycol was used with a triglyceride-lowering drug--a fibrate
named gemfibrizol--the rhabdomyolysis rate skyrocketed to more than one case per year for every 10 people treated.
44) Because of its LDL cholesterol-lowering effect, therefore, fenofibrate may be the fibrate
of choice for combination therapy with statins in the treatment of patients with HIV-associated dyslipidemia.