Abbott's TriLipix is part of a class of drugs called fibrates
that raise "good" HDL cholesterol while reducing triglycerides and "bad" LDL cholesterol.
Initial treatment is directed at the predominant abnormality, using a fibrate
for patients with predominant hypertriglyceridaemia and a statin if high LDLC is the major problem.
Although human liver expresses around 10-fold less PPAR[alpha] mRNA than the rodent liver (27,28), evidence suggests that the hypolipidemic effects of the fibrate
drugs in humans are also mediated by activation of PPAR[alpha], leading to regulation of the apolipoprotein (Apo) genes such as ApoA1 (29).
Treatment of moderate hypertriglyceridemia with fibrates
has not been shown to reduce CV or total mortality.
They received dietary restrictions, omega3 fatty acid, statin, and/or fibrate
Combination therapy with fibrates
or niacin is common clue to concurrent high TG and low HDL levels in these patients (A).
This collaboration has the potential to provide physicians and patients with the first statin and fibrate
combination in a single pill to comprehensively manage lipids.
Combinations consisting of a statin and niacin are the most popular, but combinations of a statin and a fibrate
or a statin and a bile acid sequestrant are also used.
refer to clinical studies on clofibrate and gemfibrozil in male subjects as providing evidence of "an absence of a human cancer risk" for fibrate
Fenofibrate is the preferred fibrate
to use in combination with a statin.
are also associated with rare hepatotoxicity and rhabdomyolysis, especially when combined with statins; therefore, liver function and creatine kinase (CK) levels should be checked 6 weeks after initiating fibrate
therapy and every 3 to 6 months thereafter, or if symptoms appear.
There is also evidence that serum GGT activity decreases in hypertriglyceridemic patients after treatment with a fibrate