fetal hydantoin syndrome
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Related to fetal hydantoin syndrome: fetal alcohol syndrome
fe·tal hy·dan·to·in syn·drome
a syndrome resulting from maternal ingestion of hydantoin analogue (for example, phenytoin), characterized by growth deficiency, mental deficiency, dysmorphic facies, cleft palate and/or lip, cardiac defects, and abnormal genitalia.
fetal hydantoin syndrome (FHS)
a complex of birth defects associated with prenatal maternal ingestion of hydantoin derivatives. Symptoms of FHS include microcephaly, hypoplasia or absence of nails on the fingers or toes, abnormal facies, mental and physical retardation, and cardiac defects. The syndrome occurs to some degree in 10% to 40% of infants born of mothers who use this anticonvulsant. Hydantoin is sometimes associated with hemorrhage and, more rarely, with neural crest tumors in the newborn.
fetal hydantoin syndromeA congenital complex caused by in utero exposure to anticonvulsants, affecting the infants of pregnant ♀ being treated with these agents Clinical Growth retardation, microcephaly, midfacial hypo- or dysplasia, hypertelorism, short nose, broad depressed nasal bridge, cleft lip and palate, onychodigital dysplasia, cardiac malformations, mental retardation, rarely neuroblastoma. See Fetal trimethadione syndrome.
fe·tal hy·dan·to·in syn·drome(fētăl hī-dantō-in sindrōm)
Syndrome resulting from maternal ingestion of a hydantoin analogue; involves growth deficiency, mental deficiency, dysmorphic facies, cleft palate and/or lip, and cardiac defects.