In the cell, iron is reduced to the ferric form and exported to the blood by ferroportin 1
[solute carrier family 40 (iron-regulated transporter), member 1; SLC40A1, formerly FPN1] at the basolateral membrane.
The identification of ferroportin 1
B may explain how high ferroportin expression is possible in duodenal epithelial and erythroid precursor cells during high intracellular iron levels.
Iron overloading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages.
Functional consequences of ferroportin 1 mutations.
Novel mutation in ferroportin 1
gene is associated with autosomal dominant iron overload.
Interferon-gamma and lipopolysaccharide down-regulate the macrophage iron transporter ferroportin 1
expression, thus inhibiting iron export from macrophages, a hepcidin-mediated process.
Once absorbed, iron may be stored as ferritin in the enterocytes, or it may cross the enterocyte and be exported into the circulation by another iron transport protein, ferroportin 1 (fpn1).
Ferroportin 1 is required for normal iron cycling in zebrafish.
Apical location of ferroportin 1
in airway epithelia and its role in iron detoxification in the lung.
Ferroportin 1 is a protein implicated in the efflux of iron out of cells such as enterocytes or macrophages (Fig.
Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3).
Finally, an atypical form of HH with dominant transmission is associated with the ferroportin 1
gene on chromosome 2 (OMIM 604353).