Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1
overexpression and down-regulated by hepcidin.
Hepcidin is also considered as a master regulator in the management of cellular iron homeostasis by binding to iron exporter protein ferroportin 1
(Fpn1) in cell membranes and causing its subsequent internalization and lysosomal degradation .
Functional consequences of ferroportin 1
In the cell, iron is reduced to the ferric form and exported to the blood by ferroportin 1
[solute carrier family 40 (iron-regulated transporter), member 1; SLC40A1, formerly FPN1] at the basolateral membrane.
The identification of ferroportin 1
B may explain how high ferroportin expression is possible in duodenal epithelial and erythroid precursor cells during high intracellular iron levels.
Iron overloading and erythrophagocytosis increase ferroportin 1
(FPN1) expression in J774 macrophages.
Novel mutation in ferroportin 1
gene is associated with autosomal dominant iron overload.
Interferon-gamma and lipopolysaccharide down-regulate the macrophage iron transporter ferroportin 1
expression, thus inhibiting iron export from macrophages, a hepcidin-mediated process.
Once absorbed, iron may be stored as ferritin in the enterocytes, or it may cross the enterocyte and be exported into the circulation by another iron transport protein, ferroportin 1
Apical location of ferroportin 1
in airway epithelia and its role in iron detoxification in the lung.
is a protein implicated in the efflux of iron out of cells such as enterocytes or macrophages (Fig.
Finally, an atypical form of HH with dominant transmission is associated with the ferroportin 1
gene on chromosome 2 (OMIM 604353).