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ferrochelatase

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.01 sec.
ferrochelatase
an enzyme involved in the incorporation of elemental iron into the hemoglobin synthesis cycle. Called also heme synthetase.
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This reduction in ferrochelatase activity frees protoporphyrin to accept zinc, resulting in the formation of zinc protophorphyrin, which is characteristically increased in both lead poisoning and iron deficiency.
Lead and [delta]-aminolevulinic acid dehydratase polymorphism: where ... by Fowler, Bruce A. / Environmental Health Perspectives
Pb also interferes with the normal functioning of the intramitochondrial enzyme ferrochelatase, which is responsible for the chelation of iron by protoporphyrin.
A critical review of biomarkers used for monitoring human exposure to ... by Parsons, Patrick J. / Environmental Health Perspectives
We hypothesized that the different bioavailability of PbB determined by ALAD isotypes differentially affects ferrochelatase activity and therefore Hb synthesis.
The protective effect of [delta]-aminolevulinic acid dehydratase 1-2 ... by Lee, Byung-Kook / Environmental Health Perspectives
 
 
 
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