Fen-Phen


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fen-phen

(fĕn′fĕn′)
n.
A combination of two drugs, fenfluramine hydrochloride and phentermine, formerly prescribed for weight loss but withdrawn from the market in 1997 because of potentially dangerous side effects.

Fen-Phen

Cardiology A once-popular combination of 2 anorectic agents, fenfluramine and phentermine; the theoretical advantage of using 2 different agents is that the dose of each agent could be lowered Adverse effects The fen-phen combination is associated with valvular heart disease and fatal pulmonary HTN; it was withdrawn from the market. See Fenfluramine.

Fen-Phen

(fen´-fen´),
n a combination of fenfluramine hydrochloride and phentermine hydrochloride, two stimulants, which promotes weight loss by reducing appetite. It is no longer available due to its damaging of the heart's valves. Thus it is important for a patient who has a history of using this medication to get a cardiac screening to check for risk of bacterial endocarditis. See also fenfluramine hydrochloride and phentermine hydrochloride.
References in periodicals archive ?
Crary notes that he has successfully used medication to improve the heart's pumping power in some fen-phen patients who have serious valve disease.
She discovered the link to fen-phen and fought to get the evidence reported to Wyeth and the FDA.
Made up of fenfluramine and phentermine, fen-phen was widely prescribed in the 1990s as a safe and effective way to lose weight.
The fen-phen thing collapsing will turn out to be a big driver in this segment," he notes.
Now, the researchers have defined a circuit in the brain that explains the ways fenfluramine, a component of Fen-phen, suppresses appetite.
To illustrate the types of complications that bedevil back-end opt-out rights, Part II describes a massive class action lawsuit filed on behalf of millions of users of the diet drugs known as fen-phen, which were found to cause heart problems.
He insists that Wyeth has largely pushed its fen-phen and hormone therapy troubles into boxes that it can measure, wrap up and put aside.
In the 1990s, fen-phen was widely prescribed, with as many as 18 million prescriptions written in 1996 alone (Pitts, Crosby, Laufenberg, Meidinger, & Monson, 1998).
For example, in the Fen-Phen product liability trial, the cost of discovery for a pharmaceutical company retrieving records from backup tapes was estimated at almost $2 million.
Despite the eye-popping headlines about billion-dollar fen-phen verdicts or David v.
In addition, certain medications, particularly diet pills such as Fen-Phen (a combination of fenfluramine and phentermine that was taken off the market several years ago) may cause this condition.
In 1996 the FDA approved the diet drug Redux--which later had to be withdrawn, along with another weight-loss medication involved in the deadly fen-phen scandal--after its lead reviewer warned of "severe life-threatening risk.