Fc receptor

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Related to Fc receptor: Complement receptor, ADCC

Fc re·cep·tor

receptors present on a variety of cells for the Fc fragment of immunoglobulins. These receptors recognize immunoglobulins of the IgG and IgE class.

Fc receptor

A receptor on phagocytes (neutrophils, monocytes, and macrophages) that binds Fc fragments of immunoglobulins G and E.
See: immunoglobulin; macrophage processing; phagocytosis
See also: receptor


1. a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing some effect in the cell, e.g. the cell-surface receptors of immunocompetent cells that recognize antigens, complement components or lymphokines, or those of neurons and target organs that recognize neurotransmitters or hormones; see also opioid receptors.
2. a sensory nerve ending that responds to various stimuli, e.g. arterial stretch, baroreceptors, cold, Golgi tendon organs, joint, muscle and tendon, olfactory, retinal, taste and warmth.

receptor activation
the cell of a sensory receptor responds to a specific energy change in its environment and initiates a corresponding sensory input.
adrenergic r's
receptors for epinephrine or norepinephrine, such as those on effector organs innervated by postganglionic adrenergic fibers of the sympathetic nervous system. Classified as α-adrenergic receptors, which are stimulated by norepinephrine, and β-adrenergic receptors, which are stimulated by epinephrine. See also adrenergic receptors.
autonomic r's
includes adrenergic and muscarinic receptors.
cholinergic r's
receptor sites on effector organs innervated by cholinergic nerve fibers and which respond to the acetylcholine secreted by these fibers. There are two types: muscarinic receptors and nicotinic receptors.
complement receptor
a cell-surface receptor capable of binding activated complement components. For example, component C3b is bound to neutrophils, B lymphocytes and macrophages.
dopamine r's
there are dopamine-inhibitory and dopamine-excitatory receptors.
drug receptor
a component of tissue with which a drug reacts. Classified according to the type of drugs that react with them.
Fc receptor
bind immunoglobulins via Fc part of the molecule.
histamine r's
receptors for histamine, classified as H1-receptors, which produce bronchoconstriction and contraction of the gut and are blocked by antihistamines, such as mepyramine or chlorpheniramine, and H2-receptors, which produce gastric acid secretion and are blocked by H2-receptor blockers, such as cimetidine.
muscarinic receptor
see muscarinic receptors.
nicotinic receptor
see nicotinic receptors.
peripheral receptor
sensory receptors including cutaneous warm and cold, dermoreceptors touch and pain plus receptors in the mucosae.
sensory receptor
an endorgan at the end of an afferent neuron which is capable of stimulation by a specific change, physical or chemical, in the internal or external environment of the patient.
toll-like r's
a family of transmembrane proteins that differentially recognize pathogen-associated molecular patterns through an extra cellular domain and initiate inflammatory signaling pathways through an intracellular domain; they play a central role in the innate immune response to pathogens.
receptor tyrosine kinases
a large class of cell-surface receptors with tyrosine-specific protein kinase activity.
References in periodicals archive ?
Arthron has a very strong intellectual property position covering both the Fc receptor and the drug compounds that target the receptor and believes that as a result it can avoid the patent disputes which have impacted upon other participants in this field.
A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.
Note that the control surface coated with PBS alone or normal IgGs failed to capture MNCs, suggesting that the cells were captured in the sP- or antibody-coated devices primarily owing to the interaction of adhesion molecules with the cells and not because of nonspecific binding to the renathane surface or Fc receptor.
The patent describes methods of increasing certain receptors (Fc receptors) on white blood cells or macrophages, as well as inducing Fc receptors in cells that do not normally possess them, such as lung and liver cells.
The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin.
How does the engagement of Fc receptors activate inflammatory cells to respond?
The technology offers the broadest range of specific Fc receptor activation currently available in the most "development friendly" format which can be used with any production cell line system and does not involve complex manipulations of highly heterogeneous carbohydrate molecules.
David Maloney of the Fred Hutchinson Cancer Research Center on Monday analyzing the role of Fc receptor polymorphisms on the outcome of treatment with Rituxan followed by Specifid.
Ravetch's prior work led to the cloning and mapping of the first malarial parasite chromosome, and more recently to the cloning of the first Fc receptor genes.
Together with its partner Genzyme, MacroGenics is also developing a CD16 monoclonal antibody and a soluble Fc receptor fusion protein to treat immune complex-mediated autoimmune diseases such as idiopathic thrombocytopenia purpura (ITP) and lupus.
Researchers at Xencor engineered XmAb5871 to inhibit the activation of B cells by enabling crosslinking of the B cell antigen receptor (BCR) and the inhibitory Fc receptor, FcgRIIb, via the antigen CD19, a part of the BCR coreceptor complex.
The Fcgamma receptor, CD32B (FcgammaRIIB), is the predominant Fc receptor on hematopoietic (blood) cells, such as B cells, where it plays a regulatory and cell signaling role in determining cellular function.