Fc fragment


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Related to Fc fragment: Surface immunoglobulin

Fc frag·ment

the crystallizable fragment of an immunoglobulin molecule composed of the constant regions of the heavy chains and responsible for binding to antibody receptors (Fc receptor) on cells and the Clq component of complement.
Synonym(s): Fc piece

Fc frag·ment

, Fc (frag'mĕnt)
The crystallizable fragment of an immunoglobulin molecule composed of part of the heavy chains and responsible for binding to antibody receptors on cells and the Clq component of complement.

Fc fragment

A small piece of an immunoglobulin (an antibody) used by macrophages in processing and presenting foreign antigens to T lymphocytes.
See: immune response; macrophage processing

Fc fragment

a portion of an immunoglobulin molecule, produced by papain digestion, with parts of two heavy chains. It has no antigen-combining sites, but contributes to a number of effector functions such as the binding of antibody to Fc receptors on a variety of cells, the transfer of antibody from the circulation into colostrum, the transfer across the gut of the newborn, and the binding of complement.
References in periodicals archive ?
That's because chicken Fc fragments can't trigger the so-called complement cascade in humans -- the intense inflammatory reaction that underlies many of the more serious symptoms of serum sickness and anaphylaxis.
Virdante plans to pursue development of a second drug, a sialylated recombinant IgG Fc fragment ("sFc"), the segment of IgG responsible for the anti-inflammatory activity of IVIG.
4] Human genes: GALC, galactosylceramidase; ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain; ACADVL, acyl-CoA dehydrogenase, very long chain; GALT, galactose-1-phosphate uridyl transferase; PAH, phenylalanine hydroxylase; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); RPP30, ribonuclease P/MRP 30kDa subunit.
Ravetch has further shown that these anti-inflammatory properties can be reproduced with a fully recombinant preparation of appropriately sialylated IgG Fc fragments (sFc), providing a more efficacious and potent treatment at lower dose levels.
The company has shown that its proprietary format Fcab(TM)), an antigen binding Fc fragment, can display antibody functionality such as effector functions and long half-life despite its much smaller size compared to full antibodies.
4] Human genes: IGHG1 human IgG1 heavy chain constant region; IGHG4 human IgG4 heavy chain constant region; and IGHE, human IgE heavy chain constant region; FCERIA, Fc fragment of IgE, high affinity I, receptor for; alpha polypepfide; FCER1G, Fc fragment of IgE, high affinity I, receptor for; gamma polypepfide; MS4A2, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for beta polypeptide).
2] fragment, whereas the remaining 331 samples contained heterophilic antibodies directed against the murine Fc fragment.
Humanization of animal antibodies (15) and modification of assay antibodies by removal of the Fc fragment (16) are well-known methods that often dramatically reduce interference.
Initial studies showed that this interference mostly could be solved by the removal of the Fc fragment from the capture antibody, an indication of the presence of heterophilic antibodies.