FBXW11

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FBXW11

A gene on chromosome 5q35.1 that encodes a so-called F-box protein, which contains a 40 amino acid protein-interacting motif (the F box). F-box proteins form a complex with SKP1 and cullin, resulting in phosphorylation-dependent ubiquitination and ubiquitin-mediated degradation of targeted proteins. F-box proteins are divided into three classes based on the presence of:
(1) WD-40 repeats—as is the case with this F-box protein (Fbws class);
(2) leucine-rich repeats (Fbls class); or
(3) the presence or absence of other protein-protein-interacting domains (Fbxs class).

Molecular pathology
FBXW11 has been linked to pseudotrisomy 13 syndrome.
References in periodicals archive ?
There will be a full round-up and pictures from FBW11 in next Wednesday's Business Post.
FBW11 includes a programme of keynote speakers (including representatives from the Bank of England and the Institute of Directors), workshops and factory tours.
Mold's AGS Security is the headline sponsor, while Saltney-based Parkway Telecom supported the FBW11 magazine and Women into Business Award.
A spoKesperson for the FBW11 team said: "The response has been fantastic but time is running out for people to advertise.
FBW11 magazine launch; Paul Maddocks, Jonathan Turner and Stephen Mosley MP
Paul Maddocks of Parkway Group, Cllr Arnold Woolley and Cllr Matt Wright at FBW11 magazine launch
FBW11 will also include a programme of keynote speakers (including representatives from the Bank of England and the Institute of Directors), seminars, workshops, and factory tours.