FAS

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Related to Fas receptor: Fas protein, FASL

Fas

A receptor present in cells that binds with Fas ligand to induce apoptosis.
See also: Fas ligand.

FAS

abbr.
1. fetal alcohol syndrome
2. Foreign Agricultural Service
3. free alongside ship

FAS

abbreviation for fetal alcohol syndrome.

FAS

A gene on chromosome 10q24.1 that encodes a member of the TNF-receptor superfamily which is a receptor for TNFSF6/FASLG. FAS contains a so-called death domain, and plays a central role in regulating apoptosis. Ligand binding to FAS results in the formation of a death-inducing signalling complex, comprised of Fas-associated death domain protein (FADD), caspase 8 and caspase 10.

Molecular pathology
FAS has been implicated in the pathogenesis of cancer and immune diseases.

FAS

Fetal alcohol syndrome, see there.

FAS

Abbreviation for fetal alcohol syndrome.

Fas

(fas)
A receptor present in cells that binds with Fas ligand to induce apoptosis.
See also: Fas ligand
References in periodicals archive ?
Pcy treatment of SW620 cells caused a 22-fold (after 24 h) and 35-fold (after 48 h) increase of the Fas receptor transcripts, as measured by real time RT-PCR when compared to untreated cells (Figure 1C).
The Fas receptor agonist (CH-11), when used as a single drug, caused DNA damage in SW480 cells but not in the metastatic SW620 cells.
To investigate the correlation between Fas receptor expression and apoptosis, cells were pre-treated with blocking anti-Fas ZB4 for 1 h before DMSO (control), Pcy and/or agonist anti-Fas CH-11 treatments for 48 h.
We investigated the involvement of the Fas receptor pathway in the Pcy-induced apoptotic response of human colon adenocarcinoma SW480 cells and their derived metastatic SW620 cells.
We observed that untreated SW480 cells expressed Fas receptor at a higher level than for SW620 cells in which the expression of the Fas receptor was only marginal, agreeing with previous reports (8,14).
The apoptotic signaling pathway activated by the Fas receptor leading ultimately to caspase-3 activation is mediated through two main pathways: the DISC/ caspase-8, and the mitochondria/cytochrome C/Apaf1/caspase-9 pathways.
According to the recent study, the phony version of Fas receptors on the cancer cells binds with Fas ligand, preventing it from hooking up with real Fas receptors and from starting the apoptosis cascade, researchers report in the Dec.
It is interesting to consider that the Fas receptor has been reported to be localized in cholesterol- and sphingomyelin-rich membrane rafts (Hueber et al.