Fas ligand


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Related to Fas ligand: Fas protein, CD95, Fas receptor, Granzyme B

Fas ligand

a molecule on the surface of cytotoxic T cells that binds to its receptor, Fas, on the surface of other cells, initiating apoptosis in the target cell.

Fas li·gand

(fas lī'gand)
A molecule on the surface of cytotoxic T cells that binds to its receptor, Fas, on the surface of other cells, initiating apoptosis in the target cell.
See also: Fas

fas ligand

Abbreviation: FasL
A protein on the surface of activated T cells that binds to Fas receptors on the surface of the same or other T cells and triggers a series of events causing apoptosis. This process is involved in the activation-induced cell death necessary to ensure that autoreactive T cells do not attack “self” antigens.
See also: ligand
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References in periodicals archive ?
Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?
Table 1 List of various pro-apoptotic and anti-apoptotic factors involved in the sepsis Pro-apoptotic factors Anti-apoptotic factors BAX Bcl-2 Bcl-xs Bcl-xl, Bcl-Al BIM, PUMA, NOXA Inhibitor of apoptosis proteins FAS ligand Mcl-1 Tumour necrosis factor- a Ras factor- a BID, BAK Apoptosis-inducing factor p53 BAX=Bcl-2-associated X protein, Bcl=B cell lymphoma, BIM=Bcl-2-interacting moderator of cell death, PUMA=p53- upregulated modulator of apoptosis, NOXA=phorbol-12 myristate-l-acetate-induced protein, FAS=cell surface Fas receptor also known as CD95L, Mcl=M cell lymphoma, Ras=rat sarcoma, BID=BH3 interacting death domain, BAK=Bcl-2 homologous antagonist killer.
However, there was no separate consent obtained for the estimation of soluble Fas antigen and Fas ligand which was done archived samples.
Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back.
The study hints that Fas and Fas ligand may play a role that is fundamental to tumor growth, he says.
Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication.
The cell-death-inducing Fas ligand (FasL) has also emerged in another arena.
Some guardian lymphocytes, particularly T cells, wield a molecule called Fas ligand (FasL) against outlaw cells.
Recent studies with others demonstrated that Sertoli cells also can kill activated T cells by programmed cell death, or apoptosis, through interaction with the Fas ligand molecule.
Instead, the tissues appear to produce a molecule, known as Fas ligand, that kills immune cells approaching with destructive intent.