A 33 year old man took a single tablet of Fansidar
(sulfadoxine and pyrimethamine) and chloroquine in preparation for a trip to Pakistan.
in 25 mg/kg concentration (100 [micro]l) were fed by gavage every day for 12 days after infection in malaria mice.
Resistance to other antimalarial drugs, such as chloroquine and fansidar
, has previously spread from Southeast Asia to Africa, providing a chilling precedent for such a scenario.
They are instead using fansidar
or oridar - an old line medication that is now useless against many strains of the parasite.
all resistant cases were of RI level and responded to Fansidar
treatments (Table III).
, which acts to inhibit folate synthesis in falciparum, may select for pneumococci resistant to folate antagonists, and such selection has been documented among children receiving the drug in Malawi.
When he contracted malaria last week, she gave him Fansidar
, a commonly prescribed antimalarial drug here.
Other drugs to note are Artesunate, Fansidar
(sulfadoxine/pyrimethamine), and chloroquine/proguanil, because they sometimes will be taken by travelers who have symptoms while still overseas.
Most African countries reluctantly cling to chloroquine and sulfadoxine-pyrimethamine, commonly known as fansidar
or the insignificantly better combination of both, because Artemisinin-class Combination Therapy (ACT) is 10 times more expensive and, therefore, unaffordable to them.
Alternative drugs -- such as Fansidar
and amodiaquine -- were introduced but proved to be unacceptably toxic, and they were withdrawn from use after several travelers died.
Plasmodium falciparum strains resistant to chloroquine, fansidar
, and mefloquine are widespread.
The dissolution profile for Fansidar
met stated tolerance limits, but the locally manufactured generic tablets did not.