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Apo-Famciclovir (CA), Famvir, PMS-Famciclovir (CA), Sandoz Famciclovir (CA)

Pharmacologic class: Synthetic nucleoside

Therapeutic class: Antiviral

Pregnancy risk category B


Converts to penciclovir and selectively inhibits DNA polymerase and viral DNA synthesis


Tablets: 125 mg, 250 mg, 500 mg

Indications and dosages

Acute herpes zoster infection (shingles)

Adults: 500 mg P.O. q 8 hours for 7 days

Recurrent genital herpes in immunocompetent patients

Adults: 1,000 mg P.O. b.i.d. for 1 day, starting as soon as symptoms appear

Suppression of recurrent genital herpes

Adults: 250 mg P.O. b.i.d. for up to 1 year

Recurrent herpes simplex infection in patients with human immunodeficiency virus

Adults: 500 mg P.O. b.i.d. for 7 days

Herpes labialis (oral herpes simplex) in immunocompetent patients

Adults: 1,500 mg P.O. as a one-time dose given as soon as symptoms appear

Dosage adjustment

• Renal impairment


• Hypersensitivity to drug or its components


Use cautiously in:
• renal or hepatic impairment
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 18.


• Know that for best response, therapy should begin within 6 hours of onset of genital herpes symptoms or lesions.
• Give with or without food.

Adverse reactions

CNS: headache, fatigue, dizziness, drowsiness, paresthesia, insomnia

EENT: pharyngitis, sinusitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia

Musculoskeletal: back pain, joint pain

Skin: pruritus, rash

Other: fever


Drug-drug.Digoxin: increased digoxin blood level, increased risk of toxicity

Probenecid: increased blood level of penciclovir (active antiviral compound of famciclovir)

Patient monitoring

• When giving concurrently with digoxin, monitor digoxin blood level and evaluate for digoxin toxicity.
• Monitor CBC, blood urea nitrogen, creatinine, and electrolyte levels.
• Be aware that drug may take several weeks to reach therapeutic level.
• Know that renal failure may raise blood drug level, increasing the risk of adverse reactions.
• Avoid direct contact with infected areas. Wash hands frequently and wear gloves during patient contact.

Patient teaching

• Instruct patient to take with food or milk to avoid upset stomach.
• Inform patient that drug doesn't cure herpes but only decreases pain and itching by allowing sores to heal and preventing new ones from forming.
• Advise patient to wear loose-fitting clothing to avoid irritating lesions.
• Tell patient to report rash or itching.
• Instruct female patient to tell prescriber if she is pregnant or breastfeeding.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.


A trademark for the drug famciclovir.


a trademark for an antiviral drug (famciclovir).


A brand name for FAMCICLOVIR.
References in periodicals archive ?
The company obtained marketing approval for Famvir (Generic name: famciclovir) in Japan, where it has been distributed under license by Maruho for the indication of herpes zoster (shingles) since July 2008.
Famvir significantly reduced the time to healing of non-aborted lesions, as well as time to resolution of studied symptoms in RGH patients with lesions by almost two days.
As part of the divestitures, the companies have already announced the sale of Kytril to Roche Holding and Famvir to Novartis.
Comment: In the multinational study of 329 immunocompetent adults, the benefits of 1 day of Famvir 1,000 mg b.
Recent antiviral drugs, Valtrex and Famvir, are absorbed very quickly and seem to halt progression of the condition.
Although such antiviral drugs as Zovirax, Valtrex, and Famvir may shorten an attack, they do not eliminate the infection.
For the most recent twelve months ending December 2010, Famvir and its generics had total U.
Famvir is part of the Novartis Infectious Diseases Business Franchise which is committed to the development and marketing of innovative drugs in the field of anti-virals (with emphasis on hepatitis B and C), anti-bacterials (focusing on respiratory tract infections), and Tropical Medicine (focusing on malaria).
And it is selling herpes treatments Famvir and Vectavir/Denavir to Novartis for pounds 1.
Presently the therapeutic regimen for Herpes Simplex is dominated by a range of DNA polymerase inhibitors which include Zovirax, Famvir, Valtrex, Denavir and OTC products such as Abreva and Aviralex.
In their joint statement, Glaxo and SmithKline said they expected to have to divest herpes drug Famvir and nausea product Kytril in the US, adding it was possible that one or more minor additional products with insignificant revenues would also be sold.
Analysts expect US regulators to follow the European ruling that SmithKline disposes of cancer-related nausea drug Kytril and herpes treatment Famvir.