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challenge /chal·lenge/ (chal´enj)

1. to administer a substance to monitor for the normal physiological response.

2. in immunology, to administer an antigen to monitor the response in a sensitized person.

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challenge,

1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. A small amount may be injected to determine whether the immune system will react by producing appropriate antibodies.

2 a term used to describe the rapid or concentrated infusion of a substance such as potassium or magnesium in the face of a life-threatening deficiency or a rapid infusion of IV fluid to differentiate between fluid deficit or renal failure as the cause of severely decreased urine output.

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challenge,

n a stimulating or de-manding circumstance. To develop effective problem-solving skills and strategies, it is necessary to perceive such circumstance as inconvenience or burden instead of overwhelming impediments.

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challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response