polyneuropathy

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Related to Familial amyloid polyneuropathy: Amyloid angiopathy

polyneuropathy

 [pol″e-noo͡-rop´ah-the]
a disease involving several nerves.
amyloid polyneuropathy polyneuropathy caused by amyloidosis; symptoms may include dysfunction of the autonomic nervous system, carpal tunnel syndrome, and sensory disturbances in the extremities.
familial amyloid polyneuropathy autosomal dominant amyloid polyneuropathy occurring in hereditary amyloidosis; subtypes include Finnish type, Indiana type, Iowa type, and Portuguese type. The Finnish and Indiana types are slowly progressive, whereas in the Portuguese and Iowa types death may occur within 7 to 10 years.
erythredema polyneuropathy acrodynia.

pol·y·neu·rop·a·thy

(pol'ē-nū-rop'ă-thē),
1. A disease process involving a number of peripheral nerves (literal sense).
2. A nontraumatic generalized disorder of peripheral nerves, affecting the distal fibers most severely, with proximal shading (for example, the feet are affected sooner or more severely than the hands), and typically symmetrically; most often affects motor and sensory fibers almost equally, but can involve either one, either solely or very disproportionately; classified as axon degenerating (axonal), or demyelinating; many causes, particularly metabolic and toxic; familial or sporadic. Synonym(s): polyneuritis
[poly- + G. neuron, nerve, + pathos, disease]

polyneuropathy

/poly·neu·rop·a·thy/ (-ndbobr-rop´ah-the) neuropathy of several peripheral nerves simultaneously.
amyloid polyneuropathy  polyneuropathy associated with amyloidosis, of either the primary or the familial type; symptoms may include dysfunction of the autonomic nervous system, carpal tunnel syndrome, and sensory disturbances in the limbs.
erythredema polyneuropathy  acrodynia.
familial amyloid polyneuropathy  autosomal dominant amyloid polyneuropathy, associated with familial amyloidosis and most commonly involving a mutant form of the protein transthyretin.; it may be subclassified on the basis of affected kinships or on the basis of symptoms and the biochemical composition of the affected fibrils.

polyneuropathy

(pŏl′ē-no͝o-rŏp′ə-thē)
n.
Neuropathy involving several peripheral nerves.

polyneuropathy

[-noo͡rop′əthē]
Etymology: Gk, polys, many, neuron, nerve, pathos, disease
a condition in which many peripheral nerves are afflicted with a disorder.

polyneuropathy

Chronic inflammatory polyneuropathy, critical illness polyneuropathy, familial amyloidotic polyneuropathy, multiple neuropathy, peripheral neuropathy, polyneuritis, sensorimotor polyneuropathy Neurology The simultaneous inflammation of the motor and/or sensory components of 2 or more peripheral nerves. See Mononeuropathy.

pol·y·neu·rop·a·thy

(pol'ē-nūr-op'ă-thē)
1. A disease process involving a number of peripheral nerves (literal sense).
2. A nontraumatic generalized disorder of peripheral nerves, affecting the distal fibers most severely, with proximal shading (e.g., the feet are affected sooner or more severely than the hands), and typically symmetrically; most often affects motor and sensory fibers almost equally, but can involve either one solely or very disproportionately; classified as axon degenerating (axonal) or demyelinating; many causes, particularly metabolic and toxic; familial or sporadic in nature.
Synonym(s): polyneuritis.
3. Synonym(s): acrodynia (2) . Synonym(s): multiple neuritis.
[poly- + G. neuron, nerve, + pathos, disease]

polyneuropathy

generalized autonomic, sensory and motor neuropathy; characteristic of late-stage diabetes mellitus

pol·y·neu·rop·a·thy

(pol'ē-nūr-op'ă-thē)
1. Disease process involving several peripheral nerves (literal sense).
2. Nontraumatic generalized disorder of peripheral nerves, affecting distal fibers most severely, with proximal shading.
[poly- + G. neuron, nerve, + pathos, disease]

polyneuropathy

a disease involving several nerves. See also neuropathy.

acute idiopathic polyneuropathy
see idiopathic polyradiculoneuritis.
distal polyneuropathy of Birman cats
a noninflammatory, diffuse loss of myelinated fibers in the distal portions of the central and peripheral nervous systems, resulting in progressive hindlimb ataxia and hypermetria in young Birman kittens. Believed to be inherited as an autosomal recessive trait.
familial polyneuropathy
see Boxer progressive axonopathy, hereditary neuronal abiotrophy of Swedish Lapland dogs, giant axonal neuropathy.
hypoglycemic polyneuropathy
associated with hyperinsulinism of β-cell insulinomas; there is generalized muscle weakness, paraparesis and tetraparesis.
hypothyroid polyneuropathy
a progressive lower motor neuron disease associated with hypothyroidism.
idiopathic polyneuropathy
see idiopathic polyradiculoneuritis.
immune-mediated polyneuropathy
may occur in association with systemic lupus erythematosus in dogs.
References in periodicals archive ?
We present the first case of familial amyloid polyneuropathy (FAP) type IV in an Iranian woman with severe involvement of multiple cranial nerves, peripheral limb neuropathy, and orthostatic hypotension.
This report provides comprehensive information on the therapeutic development for Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
Ophthalmic manifestations in a Chinese family with familial amyloid polyneuropathy due to a TTR Gly83Arg mutation.
Novel drug company Isis Pharmaceuticals (NasdaqGS:ISIS) said on Wednesday that it has earned a USD1m milestone payment related to the advancement of the Phase 2/3 study of ISIS-TTRRx in patients with familial amyloid polyneuropathy (FAP).
A snapshot of the global therapeutic scenario for Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease).
Changes in renal function in patients with familial amyloid polyneuropathy treated with orthotopic liver transplantation.
Usefulness of MALDI/TOF mass spectrometry of immuno-precipitated serum variant transthyretin in the diagnosis of familial amyloid polyneuropathy.
Surgeons will transplant part of the liver of a healthy 45-year-old man into his 42-year-old wife from Nagano who is suffering from a metabolic disorder known as familial amyloid polyneuropathy (FAP), doctors said.
According to the transplant team, led by Yukihiro Inomata, a professor at the university in Kumamoto, Kumamoto Prefecture, the father has familial amyloid polyneuropathy (FAP), a slowly progressive disease that can be fatal.
Global Markets Direct's, 'Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease) - Pipeline Review, H2 2012', provides an overview of the Familial Amyloid Polyneuropathy (Transthyretin Amyloidosis, Corino de Andrade's Disease) therapeutic pipeline.
Isis is evaluating ISIS-TTRRx in a Phase 3 randomized, double-blind, placebo-controlled, international study (NEURO-TTR) in patients with familial amyloid polyneuropathy (FAP).

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