Familial Fatal Insomnia

An extremely rare autosomal dominant prion disease characterised by worsening insomnia that begins between age 30 and 60; FFI results in declining health—for lack of rest—progressive difficulties in talking, walking, mental activity; death occurs 6 months to 3 years after onset
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Familial fatal insomnia involves the thalamus, and Heidenhain's variant involves the occipital lobes.
Other human forms of the disease are also known: iatrogenic CJD -- acquired as a result of medical interventions, Kuru -- acquired by ritual cannibalistic practices amongst tribes of the Fore region of papua New Guinea, Familial Fatal Insomnia -- a rare inherited human TSE, and Gerstmann-Straussler-Schinker syndrome (GSS) -- another rare inheritable human TSE and familial CJD.
In humans, the prion diseases include CJD, Kuru, familial fatal insomnia (FFI) and Gerstmann-Straussler-Scheinker syndrome (GSS).

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