Familial Fatal Insomnia

An extremely rare autosomal dominant prion disease characterised by worsening insomnia that begins between age 30 and 60; FFI results in declining health—for lack of rest—progressive difficulties in talking, walking, mental activity; death occurs 6 months to 3 years after onset
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Familial fatal insomnia (FFI) is an autosomal dominant disease caused by a point mutation in the prion protein gene.
Familial fatal insomnia is an autosomal dominant disease caused by a point mutation in the prion protein gene
Familial fatal insomnia involves the thalamus, and Heidenhain's variant involves the occipital lobes.
In humans, the prion diseases include CJD, Kuru, familial fatal insomnia (FFI) and Gerstmann-Straussler-Scheinker syndrome (GSS).

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