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factor V Leiden

   Also found in: Wikipedia 0.03 sec.
factor V Leiden
Hematology A variant of factor V present in 3%-8% of Caucasians associated with a ↑ risk of DVT. See LETS, Hereditary thrombophilia.


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Internal jugular vein thrombosis in association with the factor V Leiden mutation.
And 1 in 20 Americans carry a gene, factor V Leiden, which can increase the risk for dangerous blood clots when combined with medical treatments (hormone replacement therapy, birth control pills) or other factors (obesity, smoking, long-haul plane flights).
The six SNP panel of markers, shown to be risk factors for thrombophilia, consisted of: factor V Leiden (FVL) and HR2A45374G, prothrombin G20210A, MTHFR C677T and A1298C, along with plasminogen activator inhibitor 1 (4G/5G) (PAI1).
 
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