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Fab
(redirected from Fabs)

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.02 sec.
Fab [f ragment, a ntigen-b inding] originally, either of two identical fragments, each containing an antigen combining site, obtained by papain cleavage of the immunoglobulin IgG molecule; now generally used as an adjective to refer to an “arm” of any immunoglobulin monomer.
digoxin immune Fab (ovine)  a preparation of antigen-binding fragments derived from specific antibodies produced against digoxin in sheep; used as an antidote to digoxin and digitoxin overdose.

Fab
Etymology: fragment, antigen-binding
originally, either of two identical fragments, each containing an antigen combining site, obtained by papain cleavage of the IgG molecule. Now it is generally used as an adjective in terms such as Fab fragment or region, referring to an "arm" of any immunoglobulin monomer, i.e., one light chain and the adjoining heavy chain VH and CH1 domains.


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