FZR1

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FZR1

A gene on chromosome 19p13.3 that encodes a key regulator of ligase activity of the anaphase-promoting complex/cyclosome (APC/C), conferring substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis (in place of CDC20) and activates the APC/C during anaphase and telophase. The APC/C degrades the substrate to ensure that cell cycle upregulators do not accumulate prematurely; at the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. FZR1 is highly expressed in the heart, liver, spleen, and in some cancer cell lines.
References in periodicals archive ?
The agency said that more than 7,000 people had reached Serbia overnight Saturday-Sunday after managing to cross from Greece to FYR Macedonia and take a train at the town of Gevgelija.
Armenia vs Slovakia; Republic of Ireland vs Russia; Andorra vs FYR Macedonia
Women's Under-19s: FYR Macedonia, Germany, Czech Republic, Wales.
com/research/d041b6/telecommunications) has announced the addition of the "Telecommunications industry in FYR Macedonia" report to their offering.
Objective : UN Women Project Office in FYR Macedonia is announcing a Request for Proposals for conducting a representative field survey for examining the underlying casues for low participation of women in the labor market in the country.
HAJDUK SPLIT striker Nikola Kalinic has been forced out of the Croatia sguad for the Euro 2008 gualifying double-header against FYR Macedonia and England because of a knee injury.
FYR Macedonia coach Srecko tanec believes Russia will pose a greater threat than England when his side take on Guus Hiddink's men in a 2008 qualifier on vember 15.
Van Nistelrooy will now miss Holland's first two 2006 World Cup qualifying matches at home to the Czech Republic on September 8 and FYR Macedonia away on October 9.
UN Women Project Office in FYR Macedonia is opening Request for Proposals for Developing media and communication products: visual materials including videos, brochure, info graphic reports and project fact sheet, as well as other promotional materials for final conference.
They will be joined by Slovenia, Latvia, Hungary, Lithuania, Belarus, Belgium, FYR Macedonia and Cyprus - all nations Wales can NOT draw.