FVL


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FVL

abbreviation for factor V-Leiden. See factor V-Leiden test.
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Our FVL light work on Raider pushes lessons learned into the Defiant build.
The US Army's thinking on the next generation FVL platforms could be said to have been influenced significantly by the campaigns that it has recently prosecuted, particularly its involvement in Afghanistan fighting Taliban and Al Qaeda insurgents since 2001.
Many studies done worldwide have shown a significant correlation between FVL and RPL.
FVL polymorphism is specific for a point mutation at position 506 in which arginine is replaced by the glutamine.
This includes testing for FVL, PGM and protein S deficiency (grade D recommendation).
Although these and other studies suggested a link between FVL and stillbirth (and perhaps other thrombophilias and stillbirth), the absolute magnitude of the association (i.
So chemotherapy, the researchers concluded, was unlikely to explain the prevalence of the FVL mutation among women with TEs in this study.
FVL and prothrombin mutation can be tested for at any time.
In brief, the PCR protocols were as follows : For FVL, 30 cycles of 94[degrees]C for 30 sec, 55[degrees]C for 40 sec and extension at 72[degrees]C for 1 min; for MTHFR and PT, 30 cycles of 94[degrees]C for 1 min, annealing at 66[degrees]C for 1 min and extension of 1 min at 66[degrees]C ; for EPCR, 30 cycles of 94[degrees]C at 1 min, annealing at 55[degrees]C for 1 min and an extension of 70[degrees]C for 3 min; for PAI-1 4G/5G, 30 cycles of 94[degrees]C for 1 min, annealing at 65[degrees]C for 45 sec, extension at 72[degrees]C for 75 sec.
An FVL allelic frequency of about 2% was initially reported in the Dutch population.
The FVL polymorphism causes--because it alters a protein C cleavage site, not allowing factor Va to be inactivated.