FUT2


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Related to FUT2: Lewis Blood Group

FUT2

A gene on chromosome 19q13.3 that encodes a Golgi membrane protein involved in synthesising an H-antigen precursor, which is required for the final step in synthesising soluble A and B antigens. FUT2 is one of two genes that encode galactoside 2-L-fucosyltransferase.
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With this study we have also shown a gene-dosage effect of the Caucasian secretor mutation, G428A, in Lewis heterozygous individuals (Le/le): the serum concentrations of CA 19-9 in FUT2 heterozygous (Se/se) individuals were higher than the concentrations in homozygous wildtype individuals (Se/Se; P = 0.
Homozygous expression of a missense mutation at nucleotide 385 in the FUT2 gene associates with the Le(a+b+) partial secretor phenotype in an Indonesian family.
Molecular basis for erythrocyte Le (a+b+) and salivary ABH partial-secretor phenotypes: expression of a FUT2 secretor allele with an A-T mutation at nucleotide 385 correlates with reduced a(1,2)fucosyltransferase activity.
Distribution of ABO blood groups, Lewis antigens, and FUT2 428 genotypes among SaV- infected children and healthy controls, Leon, Nicaragua, 2005-2006 * Variable No.
PCR Amplification of FUT2 and Determination of FUT2 428 Genotype
The FUT2 gene amplification by PCR was performed as previously described (6).
The FUT2 G428A genotyping did not show any significant differences between heterozygous secretors and homozygous secretors (OR 1.