FUS

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FUS

A gene on chromosome 16p11.2 that encodes a multifunctional protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, which is involved in pre-mRNA splicing and export of processed mRNA to the cytoplasm. FUS belongs to the FET family of RNA-binding proteins that regulate gene expression, maintain genomic integrity and process mRNA/microRNA processing.

Molecular pathology
FUS mutations cause amyotrophic lateral sclerosis type 6; a FUS/CHOP translocation (t(12;16)(q13;p11)) leads to the formation of a chimeric protein, which induces liposarcoma.

FUS

feline urological syndrome.
References in periodicals archive ?
The FUS1 nanoparticle formulation was developed and tested at M.
Introgen obtained a license to the FUS1 gene from M.
Systemic therapy with combined p53 and FUS1 nanoparticles in disseminated, metastatic lung cancers decreased the number of human lung tumors by 75 percent and cut their size by 80 percent.
Abnormalities of the p53 and FUS1 tumor suppressors are among the most common molecular defects found in human cancers.
Introgen's senior vice president, Medical and Scientific Affairs stated, "These results further support our continued clinical development of p53 and FUS1 tumor suppressor therapies.
It also induced cell death in the tumors, likely through the activation of p53 and FUS1 mediated gene functions that resulted in the killing of cancer cells but not normal cells.