FURIN


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FURIN

A gene on chromosome 15q26.1 that encodes a ubiquitous endoprotease, located in the trans-Golgi network membrane of the Golgi apparatus, which is involved in constitutive secretory pathways, cleaving proproteins at the RX(K/R)R consensus motif. Furin releases albumin, complement C3 and vWF from their respective precursors.

Furin has an inhibition peptide, which serves as an intramolecular chaperone, that is autocatalytically removed in the endoplasmic reticulum and remains non-covalently bound to furin as a potent autoinhibitor. After transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
References in periodicals archive ?
For positions upstream of P4, while P5 R-K and P6 T-F modifications have moderate enhancing effects on furin cleavage (149% and 162% of canonical rate, respectively), the P7 H-Q peptide shows a substantial increase in its cleavability (186% compared with canonical).
Members of the family of eucaryotic, subtilisin-like endoproteases that reside in the constitutive secretory pathway, which include furin, Paired Basic Amino Acid Cleaving Enzyme 4 (PACE4), Prohormone Convertase 5 (PC5), and Prohormone Convertase 7 (PC7), are prime candidates for the endoproteolytic maturation of pro-BACE.
The plasmids expressing human furin and corin were purchased from Genecopeia.
The fact that human proBNP is cleaved in rats at the site that is known to be recognized by furin, [-RAPR.
Although the precise cleavage site was not established, this finding underscores the possibility that other proteases than furin and corin maybe involved in the posttranslational endoproteolysis of proANP and proBNP.
Stretch-induced hyper trophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin.
Furin is a subtilisin-like endoprotease involved in processing a diverse array of proproteins within the secretory and endocytic pathways of a wide variety of organisms and mammalian cell types.
The putative furin cleavage site RSRR or KSISKR between gp40 and gp15 of C.
Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin.
Furin, Major Timothy Austin, Legally Funding Military Support to Stability, Security, Transition, and Reconstruction Operations, Oct.
For instance, furin levels decreased substantially in the visual cortex after blindness ensued whereas PACE 4 levels remained stable.