FURIN


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FURIN

A gene on chromosome 15q26.1 that encodes a ubiquitous endoprotease, located in the trans-Golgi network membrane of the Golgi apparatus, which is involved in constitutive secretory pathways, cleaving proproteins at the RX(K/R)R consensus motif. Furin releases albumin, complement C3 and vWF from their respective precursors.

Furin has an inhibition peptide, which serves as an intramolecular chaperone, that is autocatalytically removed in the endoplasmic reticulum and remains non-covalently bound to furin as a potent autoinhibitor. After transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
References in periodicals archive ?
Processing of proB-type natriuretic peptide: furin and corin as candidate convertases.
org/issues; Terrance Furin, "Some Strategies in Dealing with High-Stakes Testing and the Death of Social Studies Education," Penn GSE Perspectives on Urban Education 3, no.
Stretch-induced hypertrophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin.
Paul Farmer, who examined Jean-Juste in Haiti, is overseeing his cancer treatment, Furin said.
Until recently, we used to employ the word uwaki, which means "having an affair" or "committing adultery," but then it changed to furin, which is frequently used these days.
The furin originated with the Chinese, who called the bell a fung-ling, and eventually was adopted by the Japanese.
Thomas, a cell biologist in the Vollum Institute for Advanced Biomedical Research, and Jay Nelson, a molecular virologist and professor in Oregon Health Sciences University's (OHSU) department of molecular microbiology, are learning how inhibitors of enzymes or endoproteases like furin might block the invasion of pathogenic cells and halt disease.
Drobac PC, del Castillo H, Sweetland A, Anca G, Joseph JK, Furin J, et al.
As a preprohormone, preproBNP (134 AA) is processed to proBNP (108 AA), which is then cleaved by furin or corin to produce biologically active BNP (77-108, 32 AA) and the inactive fragment NTproBNP (1-76, 76 AA) (40) (Fig.
The decrease in pH induces cleavage of prM by the host protease furin, which leads to rearrangement of the virion surface into the herringbonelike lattice of E protein dimers of the mature virion, although the remaining portion of prM (pr peptide) still remains associated with the virion.
sup][35] Furin cleaves a subunit twice and then release a 26 residue fragment.
Waris, "Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-[beta]1: role of TGF-[beta]1 in HCV replication," Virology, vol.