FSHR

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FSHR

A gene on chromosome 2p21-p16 that encodes a G protein-coupled receptor for follicle stimulating hormone, which plays a key role in gonad development.

Molecular pathology
FSHR mutations cause ovarian dysgenesis type 1 and ovarian hyperstimulation syndrome.
References in periodicals archive ?
Finally, the concomitant investigation of the pattern of the IGF-1 and FSH receptor expression during the differentiation of COC provides further information on the possible synergistic actions between IGF-1 and FSH.
The FSH receptor (FSHR) is a member of the super-family of G-protein-coupled receptors; it was reported to be expressed exclusively on granulosa cells of the ovary in females and on sertoli cells of the testis in males, which mediate FSH signal transduction through the cAMP pathway (Griswold et al.
Recently, new insights have been gained in the investigation of variability in the gene that encodes FSH receptor (FSHR) gene or genes of the estrogen pathway.
12) reported an increased number of Sertoli cells found on biopsy, with normal FSH levels, which might have been due to FSH receptor hyperfunction.
The research team found that the antibodies located the FSH receptor on the cells that form the blood vessel walls in the periphery of tumors, extending both internally and externally in the immediate vicinity of the tumor.
Studies have shown tissue-specific expression of the FSH receptor (FSHR) in granulosa cells and LHR in theca cells of all growing follicles.
Learning precisely how the FSH receptor is regulated is an important step in understanding the subtle defects in signal transduction that can interfere with follicle development and female fertility and could lead to new types of fertility treatments," said McGee, who is director of reproductive endocrinology and infertility at the VCU Medical Center.
Follicle stimulating hormone (FSH) accelerates the maturation of germ cells and ovulation through stimulating and binding to the FSH receptor (FSHR) (Dankbar, 1995).
The search for more effective FSH is ongoing and oral FSH receptor agonists have been identified.
This Competitive Intelligence report on Follicle-Stimulating Hormones (FSH) provides a competitor analysis report in the development pipeline of novel recombinant, transgenic and oral FSH receptor agonists for treatment of infertility by induction of ovulation.
They do this by creating more FSH receptors - molecules on the surface of ovarian cells that jumpstart the follicle making process in response to the hormone.