AFF2

(redirected from FRAXE)
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AFF2

A gene on chromosome Xq28 that encodes a putative transcriptional activator of the AF4\FMR2 gene family, which may be involved in alternative splicing regulation.

Molecular pathology
AFF2 is associated with the folate-sensitive fragile X E locus. Fragile X E syndrome is a form of nonsyndromic X-linked mental retardation.
References in periodicals archive ?
A rapid, non-radioactive screening test for fragile X mutations at the FRAXA and FRAXE loci.
The FMR2 gene, FRAXE and non-specific X-linked mental retardation: Clinical and molecular aspects.
Fragile X screening for FRAXA and FRAXE mutations using PCR based studies: Results of a five year study.