FOXP3


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Related to FOXP3: CD25

FOXP3

A gene on chromosome Xp11.23 that encodes a member of the forkhead/winged-helix family of transcriptional regulators.

Molecular pathology
FOXP3 mutations cause immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) (X-linked autoimmunity-immunodeficiency syndrome).
References in periodicals archive ?
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.
Messenger RNA for FOXP3 in the urine of renal-allograft recipients.
Children in a community with high levels of ambient air pollution (Fresno, CA) had increased methylation of the FOXP3 locus, a locus important in Treg-cell function and asthma morbidity, compared with children residing in a low-pollution community (Palo Alto, CA) (Nadeau et al.
One of the groups, led by scientists at the University of Washington in Seattle, reports in the January NATURE GENETICS that the gene, called FOXP3, can be mutated in many ways.
Although the protein encoded by the normal form of FOXP3 influences the immune system, its mechanism remains unknown, says coauthor Hans D.
Eczema, thyroid problems, allergies, and type I diabetes also turn up in people with IPEX In type I diabetes, also called juvenile-onset diabetes, the immune system destroys insulin-making cells in the pancreas, This autoimmune reaction spurred another research team to investigate whether IPEX patients with type I diabetes are likely to have the FOXP3 mutation.
Data from the Company's most recent Phase II clinical trial in MS showed that reduced levels of FOXP3 can be restored to normal levels after repeated vaccinations with NeuroVax(TM).