FOXP3


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Related to FOXP3: CD25

FOXP3

A gene on chromosome Xp11.23 that encodes a member of the forkhead/winged-helix family of transcriptional regulators.

Molecular pathology
FOXP3 mutations cause immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) (X-linked autoimmunity-immunodeficiency syndrome).
References in periodicals archive ?
We have recently reported that FOXP3 gene expression, which is a master regulator gene for the regulatory T (Treg) cells, was significant increased in HAM/TSP group compared to CT and HAC groups.
FOXP3 expression is linked more commonly to a clinical immunocompromised state and smaller lymphoma cells, and it is negative in [CD30.
FOXP3 expression is upregulated in CD4T cells in progressive HIV-1 infection and is a marker of disease severity.
Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells.
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.
Expression of CD117 and FOXP3 is illustrated in Figure 2, and the comparisons of CD117 and FOXP3 scores for control, resolved, and unresolved groups are shown in Figures 3 and 4 respectively.
Children in a community with high levels of ambient air pollution (Fresno, CA) had increased methylation of the FOXP3 locus, a locus important in Treg-cell function and asthma morbidity, compared with children residing in a low-pollution community (Palo Alto, CA) (Nadeau et al.
In addition, mutations in other genes (IPF1, PTF1A, FOXP3, GLIS3, TCF2, EIF2AK3) may also lead to multi-system diseases including neonatal diabetes (1-3,5,10).
Liver FOXP3 and PD1/PDL1 expression is down-regulated in chronic HBV hepatitis on maintained remission related to the degree of inflammation.
In young males, an X-linked severe form of the disorder is associated with immune dysregulation and polyendocrinopathy due to a germ line mutation in the FOXP3 gene located on the X chromosome.
5) demonstrated that urine concentrations of FOXP3 mRNA, a member of the forkhead family of cell differentiation genes and a lineage-specific transcript for graft-protecting regulatory T cells, can predict reversal of acute renal allograft rejection with 90% sensitivity and 73% specificity.