FOXP2


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FOXP2

A gene on chromosome 7q31 that encodes a member of the forkhead/winged-helix family of transcription factors, which is expressed in foetal and adult brain, lung and gut. It is evolutionarily conserved, and binds hundreds of different gene promoters to regulate the expression of their cognate genes. FOXP2 is required for proper development of speech and language areas of the brain during embryogenesis, and is involved in pathways that influence language development.

Molecular pathology
FOXP2 mutations cause speech-language disorder type 1 (autosomal dominant speech and language disorder with orofacial dyspraxia).
References in periodicals archive ?
There are other important differences, more specifically concerning FOXP2 (See Berwick and Chomsky, 151-152).
FOXP2 in focus: what can genes tell us about speech and language?
That said, while most aspects of the presentation are straightforward, at various points a willingness to delve into some of the more technical language of genetics (such as FOXP2, SOX9, BRCA1, SINE, LINE1, Alus, MIR) is required.
For example, the two amino acid changes in gene FOXP2, widely associated with the emergence ol modern language and other unique human cognitive capabilities, are found in Homo sapiens and Neanderthals.
They also referred to studies in which mutations in the FOXP2 gene were discovered in members of the same family, who presented changes in the emission of speech sounds.
Hasta el momento, la ciencia solo ha podido encontrar un elemento constitutivo de ese 1% que contribuye a diferenciarnos de los primates: el gen conocido como FOXP2, que controla la funcion del habla.
One finding along these lines that excited the imagination of researchers for a while was the discovery of the FOXP2 gene thought to distinguish humans from non-languaging animals.
in both cases [that of the KE family and CS] FOXP2 haplo-insufficiency in the brain at a key stage of embryogenesis leads to abnormal development of neural structures that are important for speech and language.
According to previous medical studies, verbal dyspraxia is most commonly associated with one specific gene FOXP2 and the disorder occurs with deletion of this gene.
Afortunadamente, en el ano 2001 se empezo a sospechar que algun cambio genetico podria estar involucrado en el desarrollo del habla y el lenguaje, de modo que se sugirio el factor de transcripcion FOXP2 como responsable (Lai y cols.
Ademas, estiman que existe por lo menos un gen relacionado con el habla que fue seleccionado evolutivamente en el linaje humano y que no esta relacionado con la recursividad (el FOXP2 (1)).