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FOXP1

   Also found in: Wikipedia 0.01 sec.
FOXP1
A transcription factor that has an important role in cell transformation, differentiation and proliferation and is widely expressed in normal tissues with a predominantly nuclear location in proliferative endometrium and weak cytoplasmic staining in secretory endometerium. Loss of nuclear FOXP1 expression or mislocation in the cytoplasm is typical of malignancy—e.g., invasive endometrial carcinoma


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Similarly, the t(1;14), t(14;18), and t(3;14) translocations, bring the BCL10 gene, (17) the MALT1 gene, and the FOXP1 gene (18) under the control of the IGH gene enhancer, resulting in deregulation and overexpression of the BCL10, MALT1, and FOXP1 proteins respectively.
 
 
 
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