FOXP1


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FOXP1

(1) A transcription-factor protein encoded by FOXP1 on chromosome 3p14.1, which belongs to subfamily P of the fork-head box transcription-factor family. It has DNA- and protein-binding domains, and plays an important role in cell transformation, differentiation and proliferation.

Normal expression
FOXP1 is widely expressed in normal tissues, and has a predominantly nuclear location in proliferative endometrium and weak cytoplasmic staining in secretory endometerium.

Abnormal expression
Loss of nuclear FOXP1 expression or mislocation in cytoplasm is typical of malignancy—e.g., invasive endometrial carcinoma.

(2) A gene on chromosome 3p14.1 which encodes a winged-helix transcription-factor (FOXP1) in the fork-head box family, which has a key role in cell transformation, differentiation and proliferation.
 
Abnormal expression
FOXP1 overexpression is associated with a lower disease-free survival in diffuse, large B-cell lymphoma.
References in periodicals archive ?
TMPRSS2-ERG fusion was associated with novel prostate-specific deletion at chromosome band 3p14, which may implicate FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors.
TMPRSS2-ERG fusion was associated with novel prostate-specific deletion at band 3p14, which may implicate FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors.
FOXP1 (Forkhead box-P1) is a winged-helix transcription factor that has been demonstrated to be expressed in a subset of activated B-cell type (ABC) diffuse B-cell lymphomas (DLBCLs).
FOXP1,2,3,4 proteins are is necessary for the proper development of the brain and lung in mammals FOXP4 may play a role in the development of tumors of the kidney and larynx.
That piece is FOXP1, a member of a large gene family that helps regulate tissues throughout the body, including in the heart, lungs and brain.
In addition to traditional B-cell markers (CD19, CD20, CD22, CD79a, PAX-5), PCDLBCL-LT classically expresses BCL2, IRF4/MUM-1, and FOXP1 (Figure 1, D through F).
It is composed of diffuse, monotonous sheets of centroblasts and immunoblasts and typically expresses BCL2, IRF4/MUM1, FOXP1, BCL6, and IgM.
Bcl-6, MUM-1, and FOXP1 are usually positively expressed, while CD10 and CD138 are negative (3, 12, 17).
Similarly, the t(1;14), t(14;18), and t(3;14) translocations, bring the BCL10 gene, (17) the MALT1 gene, and the FOXP1 gene (18) under the control of the IGH gene enhancer, resulting in deregulation and overexpression of the BCL10, MALT1, and FOXP1 proteins respectively.
When comparing the human brain to the non-human primates, the researchers saw more connections among gene networks that featured FOXP1 and FOXP2.